Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin

Effect of endogenous hydrogen sulfide inhibition on structural and functional renal disturbances induced by gentamicin

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Animal models of gentamicin nephrotoxicity present acute tubular necrosis associated with inflammation, which can contribute to intensify the renal damage. Hydrogen sulfide (H2S) is a signaling molecule involved in inflammation. We evaluated the effect of DL-propargylglycine (PAG), an inhibitor of e...

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Bibliographic Details
Main Authors: H.D.C. Francescato, J.R.A. Chierice, E.C.S. Marin, F.Q. Cunha, R.S. Costa, C.G.A. Silva, T.M. Coimbra
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-03-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Inflammation
Gentamicin nephrotoxicity
DL-propargylglycine
Hydrogen sulfide
Acute tubular necrosis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300010

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