Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer
Carcinoma of the papilla of Vater is a relatively rare tumor and its coexistence with other primary sporadic cancers is very exceptional. Here we report the case of a 76-year-old man who presented with painless obstructive jaundice, pathologically elevated liver function tests and increased serum le...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-05-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/329344 |
| _version_ | 1818453900180586496 |
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| author | Anastasios J. Karayiannakis Stylianos Kakolyris Georgios Kouklakis Nikolaos Xenidis Helen Bolanaki Christos Tsalikidis Constantinos Simopoulos |
| author_facet | Anastasios J. Karayiannakis Stylianos Kakolyris Georgios Kouklakis Nikolaos Xenidis Helen Bolanaki Christos Tsalikidis Constantinos Simopoulos |
| author_sort | Anastasios J. Karayiannakis |
| collection | DOAJ |
| description | Carcinoma of the papilla of Vater is a relatively rare tumor and its coexistence with other primary sporadic cancers is very exceptional. Here we report the case of a 76-year-old man who presented with painless obstructive jaundice, pathologically elevated liver function tests and increased serum levels of carbohydrate antigen 19-9 and carcinoembryonic antigen. Endoscopic retrograde cholangiography revealed a large polypoid mass in the ampulla of Vater. A large tumor in the ascending colon was also incidentally detected by abdominal computed tomography. Endoscopic biopsies from both lesions showed adenocarcinomas. Metastases to the liver and to the hepatoduodenal ligament and hepatic artery lymph nodes were found during surgery. Right colectomy and a biliary bypass were performed. Histological analysis showed an ampullary adenocarcinoma with metastases to regional lymph nodes and the liver and a colonic adenocarcinoma with local invasion into the pericolic fat. Treatment with gemcitabine plus cisplatin was suggested postoperatively. The association of sporadic ampullary and colonic adenocarcinomas and the mutually increased risk of developing either a synchronous or a metachronous tumor following each other should be considered in patients with primary ampullary or colorectal cancer during the preoperative evaluation and postoperative follow-up of these patients. |
| first_indexed | 2024-12-14T21:46:20Z |
| format | Article |
| id | doaj.art-1ab6726edfc64eee8f4aeeabdef5ce55 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-14T21:46:20Z |
| publishDate | 2011-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-1ab6726edfc64eee8f4aeeabdef5ce552022-12-21T22:46:21ZengKarger PublishersCase Reports in Gastroenterology1662-06312011-05-015230130710.1159/000329344329344Synchronous Carcinoma of the Ampulla of Vater and Colon CancerAnastasios J. KarayiannakisStylianos KakolyrisGeorgios KouklakisNikolaos XenidisHelen BolanakiChristos TsalikidisConstantinos SimopoulosCarcinoma of the papilla of Vater is a relatively rare tumor and its coexistence with other primary sporadic cancers is very exceptional. Here we report the case of a 76-year-old man who presented with painless obstructive jaundice, pathologically elevated liver function tests and increased serum levels of carbohydrate antigen 19-9 and carcinoembryonic antigen. Endoscopic retrograde cholangiography revealed a large polypoid mass in the ampulla of Vater. A large tumor in the ascending colon was also incidentally detected by abdominal computed tomography. Endoscopic biopsies from both lesions showed adenocarcinomas. Metastases to the liver and to the hepatoduodenal ligament and hepatic artery lymph nodes were found during surgery. Right colectomy and a biliary bypass were performed. Histological analysis showed an ampullary adenocarcinoma with metastases to regional lymph nodes and the liver and a colonic adenocarcinoma with local invasion into the pericolic fat. Treatment with gemcitabine plus cisplatin was suggested postoperatively. The association of sporadic ampullary and colonic adenocarcinomas and the mutually increased risk of developing either a synchronous or a metachronous tumor following each other should be considered in patients with primary ampullary or colorectal cancer during the preoperative evaluation and postoperative follow-up of these patients.http://www.karger.com/Article/FullText/329344Ampullary carcinomaColorectal carcinomaPapilla of Vater carcinomaSecond primary cancerSynchronous cancer |
| spellingShingle | Anastasios J. Karayiannakis Stylianos Kakolyris Georgios Kouklakis Nikolaos Xenidis Helen Bolanaki Christos Tsalikidis Constantinos Simopoulos Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer Case Reports in Gastroenterology Ampullary carcinoma Colorectal carcinoma Papilla of Vater carcinoma Second primary cancer Synchronous cancer |
| title | Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer |
| title_full | Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer |
| title_fullStr | Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer |
| title_full_unstemmed | Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer |
| title_short | Synchronous Carcinoma of the Ampulla of Vater and Colon Cancer |
| title_sort | synchronous carcinoma of the ampulla of vater and colon cancer |
| topic | Ampullary carcinoma Colorectal carcinoma Papilla of Vater carcinoma Second primary cancer Synchronous cancer |
| url | http://www.karger.com/Article/FullText/329344 |
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