Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging
ObjectiveTo evaluate whether the introduction of tumor volume as new parameter in the MRI assessment could improve both concordance between preoperative and postoperative staging, and the identification of histological findings.MethodsA retrospective observational study with 127 patients with endome...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1219818/full |
| _version_ | 1797741669072764928 |
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| author | Elga López-González Rocío García-Jiménez Alberto Rodríguez-Jiménez José Antonio Rojas-Luna Cinta Daza-Manzano Juan Gómez-Salgado Juan Gómez-Salgado Rosa María Álvarez |
| author_facet | Elga López-González Rocío García-Jiménez Alberto Rodríguez-Jiménez José Antonio Rojas-Luna Cinta Daza-Manzano Juan Gómez-Salgado Juan Gómez-Salgado Rosa María Álvarez |
| author_sort | Elga López-González |
| collection | DOAJ |
| description | ObjectiveTo evaluate whether the introduction of tumor volume as new parameter in the MRI assessment could improve both concordance between preoperative and postoperative staging, and the identification of histological findings.MethodsA retrospective observational study with 127 patients with endometrial cancer (EC) identified between 2016 and 2021 at the Juan Ramon Jimenez University Hospital, Huelva (Spain) was carried out. Tumor volume was measured in three ways. Analyses of Receiver Operating Characteristic (ROC) curve and the area under the curve (AUC) were performed.ResultsAlthough preoperative MRI had an 89.6% and 66.7% sensitivity for the detection of deep mucosal invasion and cervical stroma infiltration, preoperative assessment had an intraclass correlation coefficient of 0.517, underestimating tumor final stage in 12.6% of cases, with a poor agreement between preoperative MRI and postoperative staging (κ=0.082) and low sensitivity (14.3%) for serosa infiltration. The cut-off values for all three volume parameters had good/excellent AUC (0.73-0.85), with high sensitivity (70-83%) and specificity (64-84%) values for all histopathological variables. Excellent/good agreement was found all volume parameters for the identification of deep myometrial invasion (0.71), cervical stroma infiltration (0.80), serosa infiltration (0.81), and lymph node metastases (0.81).ConclusionTumor volume measurements have good predictive capacity to detect histopathological findings that affect final tumor staging and might play a crucial role in the preoperative assessment of patients with endometrial cancer in the future. |
| first_indexed | 2024-03-12T14:30:03Z |
| format | Article |
| id | doaj.art-1ab7e48e38cf414a996a473e3db8cd9d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T14:30:03Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1ab7e48e38cf414a996a473e3db8cd9d2023-08-17T13:12:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.12198181219818Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imagingElga López-González0Rocío García-Jiménez1Alberto Rodríguez-Jiménez2José Antonio Rojas-Luna3Cinta Daza-Manzano4Juan Gómez-Salgado5Juan Gómez-Salgado6Rosa María Álvarez7Gynaecological Oncology Unit, Department of Obstetrics and Gynaecology, Hospital Universitario Juan Ramón Jiménez, Huelva, SpainGynaecological Oncology Unit, Department of Obstetrics and Gynaecology, Hospital Universitario Juan Ramón Jiménez, Huelva, SpainDepartment of Radiology, Hospital Universitario Juan Ramón Jiménez, Huelva, SpainGynaecological Oncology Unit, Department of Obstetrics and Gynaecology, Hospital Universitario Juan Ramón Jiménez, Huelva, SpainGynaecological Oncology Unit, Department of Obstetrics and Gynaecology, Hospital Universitario Juan Ramón Jiménez, Huelva, SpainDepartment of Sociology, Social Work and Public Health, Faculty of Labor Sciences, University of Huelva, Huelva, SpainSafety and Health Postgraduate Program, Universidad Espíritu Santo, Guayaquil, EcuadorGynecological Oncology and Breast Cancer Unit, Department of Obstetrics and Gynecology, Hospital Universitario Santa Cristina, Madrid, SpainObjectiveTo evaluate whether the introduction of tumor volume as new parameter in the MRI assessment could improve both concordance between preoperative and postoperative staging, and the identification of histological findings.MethodsA retrospective observational study with 127 patients with endometrial cancer (EC) identified between 2016 and 2021 at the Juan Ramon Jimenez University Hospital, Huelva (Spain) was carried out. Tumor volume was measured in three ways. Analyses of Receiver Operating Characteristic (ROC) curve and the area under the curve (AUC) were performed.ResultsAlthough preoperative MRI had an 89.6% and 66.7% sensitivity for the detection of deep mucosal invasion and cervical stroma infiltration, preoperative assessment had an intraclass correlation coefficient of 0.517, underestimating tumor final stage in 12.6% of cases, with a poor agreement between preoperative MRI and postoperative staging (κ=0.082) and low sensitivity (14.3%) for serosa infiltration. The cut-off values for all three volume parameters had good/excellent AUC (0.73-0.85), with high sensitivity (70-83%) and specificity (64-84%) values for all histopathological variables. Excellent/good agreement was found all volume parameters for the identification of deep myometrial invasion (0.71), cervical stroma infiltration (0.80), serosa infiltration (0.81), and lymph node metastases (0.81).ConclusionTumor volume measurements have good predictive capacity to detect histopathological findings that affect final tumor staging and might play a crucial role in the preoperative assessment of patients with endometrial cancer in the future.https://www.frontiersin.org/articles/10.3389/fonc.2023.1219818/fullendometrial cancertumor volumebiopsymagnetic resonance imagingpreoperative staging |
| spellingShingle | Elga López-González Rocío García-Jiménez Alberto Rodríguez-Jiménez José Antonio Rojas-Luna Cinta Daza-Manzano Juan Gómez-Salgado Juan Gómez-Salgado Rosa María Álvarez Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging Frontiers in Oncology endometrial cancer tumor volume biopsy magnetic resonance imaging preoperative staging |
| title | Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging |
| title_full | Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging |
| title_fullStr | Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging |
| title_full_unstemmed | Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging |
| title_short | Analysis of correlation of pre-therapeutic assessment and the final diagnosis in endometrial cancer: role of tumor volume in the magnetic resonance imaging |
| title_sort | analysis of correlation of pre therapeutic assessment and the final diagnosis in endometrial cancer role of tumor volume in the magnetic resonance imaging |
| topic | endometrial cancer tumor volume biopsy magnetic resonance imaging preoperative staging |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1219818/full |
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