Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Abstract: Background Intraneuronal α-synuclein (α-Syn) aggregates known as Lewy bodies (LBs) and the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) are the pathological hallmarks of Parkinson’s disease (PD). Braak’s hypothesis based on autopsy studies suggests that Lewy pa...

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Bibliographic Details
Main Authors: Norihito Uemura, Hisashi Yagi, Maiko T. Uemura, Yusuke Hatanaka, Hodaka Yamakado, Ryosuke Takahashi
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
α-synuclein
Lewy bodies
Propagation
Enteric nervous system
Vagus nerve
Online Access:http://link.springer.com/article/10.1186/s13024-018-0257-5

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