Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation
<p>Abstract</p> <p>This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid...
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| Format: | Article |
| Language: | English |
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BMC
2009-05-01
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| Series: | Chinese Medicine |
| Online Access: | http://www.cmjournal.org/content/4/1/10 |
| _version_ | 1818387293744922624 |
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| author | Fung Peter |
| author_facet | Fung Peter |
| author_sort | Fung Peter |
| collection | DOAJ |
| description | <p>Abstract</p> <p>This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis) for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. Acupuncture acting on meridian channel causes cytoskeletal remodeling through mechanotransduction, leading to regulation of gene expression and the subsequent production of related proteins. Also, stimulation on cell surface can trigger Ca<sup>2+ </sup>activities, resulting in a cascade of intra- and inter-cellular signaling. Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. Acupoint along a meridian channel is a functional site to trigger the above functions with specificity and high efficiency.</p> |
| first_indexed | 2024-12-14T04:07:39Z |
| format | Article |
| id | doaj.art-1abb626d7f5e4bf8816d15f28399697b |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-12-14T04:07:39Z |
| publishDate | 2009-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-1abb626d7f5e4bf8816d15f28399697b2022-12-21T23:17:47ZengBMCChinese Medicine1749-85462009-05-01411010.1186/1749-8546-4-10Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulationFung Peter<p>Abstract</p> <p>This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis) for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. Acupuncture acting on meridian channel causes cytoskeletal remodeling through mechanotransduction, leading to regulation of gene expression and the subsequent production of related proteins. Also, stimulation on cell surface can trigger Ca<sup>2+ </sup>activities, resulting in a cascade of intra- and inter-cellular signaling. Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. Acupoint along a meridian channel is a functional site to trigger the above functions with specificity and high efficiency.</p>http://www.cmjournal.org/content/4/1/10 |
| spellingShingle | Fung Peter Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation Chinese Medicine |
| title | Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation |
| title_full | Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation |
| title_fullStr | Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation |
| title_full_unstemmed | Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation |
| title_short | Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation |
| title_sort | probing the mystery of chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system mechanotransduction cells durotaxis and mast cell degranulation |
| url | http://www.cmjournal.org/content/4/1/10 |
| work_keys_str_mv | AT fungpeter probingthemysteryofchinesemedicinemeridianchannelswithspecialemphasisontheconnectivetissueinterstitialfluidsystemmechanotransductioncellsdurotaxisandmastcelldegranulation |