Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes
The aim of this research was to reveal the characteristics of gut microbiome altered by acarbose intervention in Japanese patients with type 2 diabetes (T2D) and its possible association with habitual dietary intake. Eighteen patients with T2D were administered acarbose for four weeks. The abundance...
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/6/2107 |
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| author | Fumie Takewaki Hanako Nakajima Daiki Takewaki Yoshitaka Hashimoto Saori Majima Hiroshi Okada Takafumi Senmaru Emi Ushigome Masahide Hamaguchi Masahiro Yamazaki Yoshiki Tanaka Shunji Nakajima Hiroshi Ohno Michiaki Fukui |
| author_facet | Fumie Takewaki Hanako Nakajima Daiki Takewaki Yoshitaka Hashimoto Saori Majima Hiroshi Okada Takafumi Senmaru Emi Ushigome Masahide Hamaguchi Masahiro Yamazaki Yoshiki Tanaka Shunji Nakajima Hiroshi Ohno Michiaki Fukui |
| author_sort | Fumie Takewaki |
| collection | DOAJ |
| description | The aim of this research was to reveal the characteristics of gut microbiome altered by acarbose intervention in Japanese patients with type 2 diabetes (T2D) and its possible association with habitual dietary intake. Eighteen patients with T2D were administered acarbose for four weeks. The abundances of two major phyla, namely Actinobacteria and Bacteroidetes, were reciprocally changed accompanied by the acarbose intervention. There were also significant changes in the abundances of ten genera, including the greater abundance of <i>Bifidobacterium</i>, <i>Eubacterium</i>, and <i>Lactobacillus</i> and the lower abundance of <i>Bacteroides</i> in the group after the intervention than that before the intervention. Hierarchical clustering of habitual dietary intake was performed based on the pattern of changes in the gut microbiota and were classified into distinct three clusters. Cluster I consisted of sucrose, cluster II mainly included fat intake, and cluster III mainly included carbohydrate intake. Moreover, the amount of change in <i>Faecalibacterium</i> was positively correlated with the intake of rice, but negatively correlated with the intake of bread. The intake of potato was negatively correlated with the amount of change in <i>Akkermansia</i> and <i>Subdoligranulum</i>. Acarbose altered the composition of gut microbiome in Japanese patients with T2D, which might be linked to the habitual dietary intake. |
| first_indexed | 2024-03-10T10:15:17Z |
| format | Article |
| id | doaj.art-1abbf483943b4d3d9edafbe7681e9341 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:15:17Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1abbf483943b4d3d9edafbe7681e93412023-11-22T00:52:09ZengMDPI AGNutrients2072-66432021-06-01136210710.3390/nu13062107Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 DiabetesFumie Takewaki0Hanako Nakajima1Daiki Takewaki2Yoshitaka Hashimoto3Saori Majima4Hiroshi Okada5Takafumi Senmaru6Emi Ushigome7Masahide Hamaguchi8Masahiro Yamazaki9Yoshiki Tanaka10Shunji Nakajima11Hiroshi Ohno12Michiaki Fukui13Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanR&D Center, Biofermin Pharmaceutical Co., Ltd., Kobe 650-0021, JapanR&D Center, Biofermin Pharmaceutical Co., Ltd., Kobe 650-0021, JapanR&D Center, Biofermin Pharmaceutical Co., Ltd., Kobe 650-0021, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, JapanThe aim of this research was to reveal the characteristics of gut microbiome altered by acarbose intervention in Japanese patients with type 2 diabetes (T2D) and its possible association with habitual dietary intake. Eighteen patients with T2D were administered acarbose for four weeks. The abundances of two major phyla, namely Actinobacteria and Bacteroidetes, were reciprocally changed accompanied by the acarbose intervention. There were also significant changes in the abundances of ten genera, including the greater abundance of <i>Bifidobacterium</i>, <i>Eubacterium</i>, and <i>Lactobacillus</i> and the lower abundance of <i>Bacteroides</i> in the group after the intervention than that before the intervention. Hierarchical clustering of habitual dietary intake was performed based on the pattern of changes in the gut microbiota and were classified into distinct three clusters. Cluster I consisted of sucrose, cluster II mainly included fat intake, and cluster III mainly included carbohydrate intake. Moreover, the amount of change in <i>Faecalibacterium</i> was positively correlated with the intake of rice, but negatively correlated with the intake of bread. The intake of potato was negatively correlated with the amount of change in <i>Akkermansia</i> and <i>Subdoligranulum</i>. Acarbose altered the composition of gut microbiome in Japanese patients with T2D, which might be linked to the habitual dietary intake.https://www.mdpi.com/2072-6643/13/6/2107type 2 diabetesgut microbiomeα-Glucosidase inhibitorsdietdietary habit |
| spellingShingle | Fumie Takewaki Hanako Nakajima Daiki Takewaki Yoshitaka Hashimoto Saori Majima Hiroshi Okada Takafumi Senmaru Emi Ushigome Masahide Hamaguchi Masahiro Yamazaki Yoshiki Tanaka Shunji Nakajima Hiroshi Ohno Michiaki Fukui Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes Nutrients type 2 diabetes gut microbiome α-Glucosidase inhibitors diet dietary habit |
| title | Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes |
| title_full | Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes |
| title_fullStr | Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes |
| title_full_unstemmed | Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes |
| title_short | Habitual Dietary Intake Affects the Altered Pattern of Gut Microbiome by Acarbose in Patients with Type 2 Diabetes |
| title_sort | habitual dietary intake affects the altered pattern of gut microbiome by acarbose in patients with type 2 diabetes |
| topic | type 2 diabetes gut microbiome α-Glucosidase inhibitors diet dietary habit |
| url | https://www.mdpi.com/2072-6643/13/6/2107 |
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