Geometric parameters that affect the behavior of logic-gated CAR T cells

Geometric parameters that affect the behavior of logic-gated CAR T cells

Clinical applications of CAR-T cells are limited by the scarcity of tumor-specific targets and are often afflicted with the same on-target/off-tumor toxicities that plague other cancer treatments. A new promising strategy to enforce tumor selectivity is the use of logic-gated, two-receptor systems....

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Bibliographic Details
Main Authors: Alexander C. Partin, Richele Bruno, Sanam Shafaattalab, Erica Vander Mause, Aaron Winters, Mark Daris, Casey Gahrs, Claudia A. Jette, Breanna DiAndreth, Mark L. Sandberg, Agnes E. Hamburger, Alexander Kamb, Timothy P. Riley
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
logic-gate
CAR (chimeric antigen receptor)
synapse
T cell
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1304765/full

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