Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer
Primary diffuse large B cell lymphoma of the breast is an uncommon form of gestational breast cancer and its presentation during pregnancy is challenging. In our case report, a patient presented with a right breast lump during the first trimester of her pregnancy. Biopsy was taken from right brea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Liaquat National Hospital and Medical College
2022-06-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/f1c09ee7-d9f9-4047-bec0-b88244647317.pdf |
| _version_ | 1811240120450285568 |
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| author | Yumna Ahmed Fatima Shaukat Agha Muhammad Hammad Khan Rabia Tahseen Maria Tariq Sehrish Abrar Nasir Ali |
| author_facet | Yumna Ahmed Fatima Shaukat Agha Muhammad Hammad Khan Rabia Tahseen Maria Tariq Sehrish Abrar Nasir Ali |
| author_sort | Yumna Ahmed |
| collection | DOAJ |
| description | Primary diffuse large B cell lymphoma of the breast is an uncommon form of gestational breast cancer and its presentation during
pregnancy is challenging.
In our case report, a patient presented with a right breast lump during the first trimester of her pregnancy. Biopsy was taken from right
breast mass, which was diffuse large b cell lymphoma (DLBCL) double expressive type. She underwent termination of pregnancy
and received 6 cycles of multiagent intense chemotherapy along with central nervous system prophylaxis followed by consolidation
involved site radiotherapy (ISRT) to breast and axilla after achieving a complete response.
Studies suggest no improvement in the outcome of gestational breast cancer with the termination of pregnancy. However, the
presentation of primary DLBCL during pregnancy is extremely rare and the decision regarding pregnancy termination is weighted
upon a case by case basis. The paucity of data makes our case report a valuable source for the management of DLBCL breast in
pregnancy. |
| first_indexed | 2024-04-12T13:14:55Z |
| format | Article |
| id | doaj.art-1abe2c6bd5fa484490d3a6aebfb42a32 |
| institution | Directory Open Access Journal |
| issn | 2707-3521 2708-9134 |
| language | English |
| last_indexed | 2024-04-12T13:14:55Z |
| publishDate | 2022-06-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj.art-1abe2c6bd5fa484490d3a6aebfb42a322022-12-22T03:31:44ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342022-06-01416971https://doi.org/10.37184/lnjpc.2707-3521.4.4Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast CancerYumna Ahmed0Fatima Shaukat1Agha Muhammad Hammad Khan2Rabia Tahseen3Maria Tariq4Sehrish Abrar5Nasir Ali6Department of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanDepartment of Radiation Oncology, CyberKnife and Tomotherapy Unit, Jinnah Postgraduate Medical Center, Karachi, PakistanDepartment of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanDepartment of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanDepartment of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanDepartment of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanDepartment of Radiation Oncology, Aga Khan University Hospital, Karachi, PakistanPrimary diffuse large B cell lymphoma of the breast is an uncommon form of gestational breast cancer and its presentation during pregnancy is challenging. In our case report, a patient presented with a right breast lump during the first trimester of her pregnancy. Biopsy was taken from right breast mass, which was diffuse large b cell lymphoma (DLBCL) double expressive type. She underwent termination of pregnancy and received 6 cycles of multiagent intense chemotherapy along with central nervous system prophylaxis followed by consolidation involved site radiotherapy (ISRT) to breast and axilla after achieving a complete response. Studies suggest no improvement in the outcome of gestational breast cancer with the termination of pregnancy. However, the presentation of primary DLBCL during pregnancy is extremely rare and the decision regarding pregnancy termination is weighted upon a case by case basis. The paucity of data makes our case report a valuable source for the management of DLBCL breast in pregnancy.https://journals.lnh.edu.pk/lnjpc/pdf/f1c09ee7-d9f9-4047-bec0-b88244647317.pdfgestational breast cancerradiotherapylymphomadouble expressorpregnancy |
| spellingShingle | Yumna Ahmed Fatima Shaukat Agha Muhammad Hammad Khan Rabia Tahseen Maria Tariq Sehrish Abrar Nasir Ali Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer Liaquat National Journal of Primary Care gestational breast cancer radiotherapy lymphoma double expressor pregnancy |
| title | Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer |
| title_full | Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer |
| title_fullStr | Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer |
| title_full_unstemmed | Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer |
| title_short | Primary Diffuse Large B-Cell Lymphoma of Breast: A Rare Form of Gestational Breast Cancer |
| title_sort | primary diffuse large b cell lymphoma of breast a rare form of gestational breast cancer |
| topic | gestational breast cancer radiotherapy lymphoma double expressor pregnancy |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/f1c09ee7-d9f9-4047-bec0-b88244647317.pdf |
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