Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells
Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structura...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700607&lng=en&tlng=en |
| _version_ | 1828451537102307328 |
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| author | Y.-J. Xiao Q.-C. Diao Y.-H. Liang K. Zeng |
| author_facet | Y.-J. Xiao Q.-C. Diao Y.-H. Liang K. Zeng |
| author_sort | Y.-J. Xiao |
| collection | DOAJ |
| description | Using two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests. |
| first_indexed | 2024-12-10T23:38:00Z |
| format | Article |
| id | doaj.art-1abe5976d2e7438c8dcd2212c071e413 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-10T23:38:00Z |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-1abe5976d2e7438c8dcd2212c071e4132022-12-22T01:29:07ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X50710.1590/1414-431x20176390S0100-879X2017000700607Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cellsY.-J. XiaoQ.-C. DiaoY.-H. LiangK. ZengUsing two flexible Schiff bases, H2L1 and H2L2, two new cobalt II (Co(II))-coordination compounds, namely, Py3CoL1 (1) and Py3CoL2 (2) (Py=pyridine, L1=3,5-ClC6H2(O)C=NC6H3(O)-4-NO2, L2=3,5-BrC6H2(O)C=NC6H3(O)-4-NO2) have been synthesized under solvothermal conditions. Single crystal X-ray structural analysis revealed that compounds 1 and 2 are both six-coordinate in a distorted octahedral geometry, and the 1D chain structure was formed by the π…π and C-H…O interactions or C-H…Cl interaction. The in vitro antitumor activities of 1, 2 and their corresponding organic ligands Py, L1, and L2 were studied and evaluated, in which three human skin cancer cell lines (A-431, HT-144 and SK-MEL-30) were used in the screening tests.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700607&lng=en&tlng=enSchiff basesCoordination compoundAntitumor activity |
| spellingShingle | Y.-J. Xiao Q.-C. Diao Y.-H. Liang K. Zeng Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells Brazilian Journal of Medical and Biological Research Schiff bases Coordination compound Antitumor activity |
| title | Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells |
| title_full | Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells |
| title_fullStr | Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells |
| title_full_unstemmed | Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells |
| title_short | Two novel Co(II) complexes with two different Schiff bases: inhibiting growth of human skin cancer cells |
| title_sort | two novel co ii complexes with two different schiff bases inhibiting growth of human skin cancer cells |
| topic | Schiff bases Coordination compound Antitumor activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000700607&lng=en&tlng=en |
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