| Summary: | Members of the <i>Flaviviridae</i> family are posing a significant threat to human health worldwide. Many flaviviruses are capable of inducing severe inflammation in humans. <i>Flaviviridae</i> nonstructural proteins, apart from their canonical roles in viral replication, have noncanonical functions strongly affecting antiviral innate immunity. Among these functions, antagonism of type I IFN is the most investigated; meanwhile, more data are accumulated on their role in the other pathways of innate response. This review systematizes the last known data on the role of <i>Flaviviridae</i> nonstructural proteins in molecular mechanisms of triggering inflammation, with an emphasis on their interactions with TLRs and RLRs, interference with NF-κB and cGAS-STING signaling, and activation of inflammasomes.
|
|---|