Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential
A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-09-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/10/11996 |
| _version_ | 1828255309043335168 |
|---|---|
| author | Hoong-Kun Fun Ching Kheng Quah Chin Wei Ooi C. S. Chidan Kumar Wan-Sin Loh |
| author_facet | Hoong-Kun Fun Ching Kheng Quah Chin Wei Ooi C. S. Chidan Kumar Wan-Sin Loh |
| author_sort | Hoong-Kun Fun |
| collection | DOAJ |
| description | A series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC50 values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent. |
| first_indexed | 2024-04-13T02:12:19Z |
| format | Article |
| id | doaj.art-1ac449f9e9a74d4faa285c7adde3fe46 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T02:12:19Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1ac449f9e9a74d4faa285c7adde3fe462022-12-22T03:07:16ZengMDPI AGMolecules1420-30492013-09-011810119961201110.3390/molecules181011996Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant PotentialHoong-Kun FunChing Kheng QuahChin Wei OoiC. S. Chidan KumarWan-Sin LohA series of six novel heterocyclic chalcone analogues 4(a–f) has been synthesized by condensing 2-acetyl-5-chlorothiophene with benzaldehyde derivatives in methanol at room temperature using a catalytic amount of sodium hydroxide. The newly synthesized compounds are characterized by IR, mass spectra, elemental analysis and melting point. Subsequently; the structures of these compounds were determined using single crystal X-ray diffraction. All the synthesized compounds were screened for their antioxidant potential by employing various in vitro models such as DPPH free radical scavenging assay, ABTS radical scavenging assay, ferric reducing antioxidant power and cupric ion reducing antioxidant capacity. Results reflect the structural impact on the antioxidant ability of the compounds. The IC50 values illustrate the mild to good antioxidant activities of the reported compounds. Among them, 4f with a p-methoxy substituent was found to be more potent as antioxidant agent.http://www.mdpi.com/1420-3049/18/10/11996heterocyclicradical scavengingreducingsubstituentoverlay |
| spellingShingle | Hoong-Kun Fun Ching Kheng Quah Chin Wei Ooi C. S. Chidan Kumar Wan-Sin Loh Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential Molecules heterocyclic radical scavenging reducing substituent overlay |
| title | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
| title_full | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
| title_fullStr | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
| title_full_unstemmed | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
| title_short | Structural Correlation of Some Heterocyclic Chalcone Analogues and Evaluation of Their Antioxidant Potential |
| title_sort | structural correlation of some heterocyclic chalcone analogues and evaluation of their antioxidant potential |
| topic | heterocyclic radical scavenging reducing substituent overlay |
| url | http://www.mdpi.com/1420-3049/18/10/11996 |
| work_keys_str_mv | AT hoongkunfun structuralcorrelationofsomeheterocyclicchalconeanaloguesandevaluationoftheirantioxidantpotential AT chingkhengquah structuralcorrelationofsomeheterocyclicchalconeanaloguesandevaluationoftheirantioxidantpotential AT chinweiooi structuralcorrelationofsomeheterocyclicchalconeanaloguesandevaluationoftheirantioxidantpotential AT cschidankumar structuralcorrelationofsomeheterocyclicchalconeanaloguesandevaluationoftheirantioxidantpotential AT wansinloh structuralcorrelationofsomeheterocyclicchalconeanaloguesandevaluationoftheirantioxidantpotential |