| Summary: | BackgroundExercise-induced desaturation (EID) is highly prevalent, and associated with the prognosis in patients with chronic obstructive pulmonary disease (COPD) . Current predicators of EID mostly depend on pulmonary function, and the assessment for their values is different.ObjectiveTo explore simple, and accurate methods suitably used in primary care to predict EID by six-minute walk test (6MWT) in patients with stable COPD.MethodsA retrospective study was conducted. Participants were 67 stable COPD patients with respiratory clinic follow-ups selected from China-Japan Friendship Hospital from 2019 to 2020. Data were collected, including assessment results of pulmonary function test, 6MWT, modified Medical Research Council (mMRC) , and COPD Assessment Test (CAT) , as well as calculated BODE index. EID in 6MWT was defined as the difference between minimum oxygen saturation in 6MWT and resting oxygen saturation at the beginning of 6MWT (ΔSpO2) ≥4%. mMRC score, CAT score and BODE index were compared between patients with and without EID in 6MWT to estimate the association of ΔSpO2 in 6MWT with mMRC score, CAT score and BODE index. ROC analysis was used to estimate the predictive value of mMRC score, CAT score and BODE index for inducible hypoxia in 6MWT.ResultsThe ΔSpO2 in 6MWT was significantly negatively correlated with mMRC score (r=-0.492, P<0.001) , CAT score (r=-0.447, P<0.001) , and BODE index (r=-0.415, P<0.001) . The AUC of mMRC score in predicting EID in 6MWT was 0.683 (with 2 as the optimal cut-off value) , and that for CAT score was 0.765 (with 14 as the optimal cut-off value) , for BODE index was 0.711 (with 2 as the optimal cut-off value) .ConclusionAll of mMRC score, CAT score and BODE index can be used to predict EID in 6MWT in patients with stable COPD.
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