Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia.
Submicroscopic Plasmodium infections are an important parasite reservoir, but their clinical relevance is poorly defined. A cross-sectional household survey was conducted in southern Papua, Indonesia, using cluster random sampling. Data were recorded using a standardized questionnaire. Blood samples...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5082812?pdf=render |
| _version_ | 1818940819344719872 |
|---|---|
| author | Zuleima Pava Faustina H Burdam Irene Handayuni Leily Trianty Retno A S Utami Yusrifar Kharisma Tirta Enny Kenangalem Daniel Lampah Andreas Kusuma Grennady Wirjanata Steven Kho Julie A Simpson Sarah Auburn Nicholas M Douglas Rintis Noviyanti Nicholas M Anstey Jeanne R Poespoprodjo Jutta Marfurt Ric N Price |
| author_facet | Zuleima Pava Faustina H Burdam Irene Handayuni Leily Trianty Retno A S Utami Yusrifar Kharisma Tirta Enny Kenangalem Daniel Lampah Andreas Kusuma Grennady Wirjanata Steven Kho Julie A Simpson Sarah Auburn Nicholas M Douglas Rintis Noviyanti Nicholas M Anstey Jeanne R Poespoprodjo Jutta Marfurt Ric N Price |
| author_sort | Zuleima Pava |
| collection | DOAJ |
| description | Submicroscopic Plasmodium infections are an important parasite reservoir, but their clinical relevance is poorly defined. A cross-sectional household survey was conducted in southern Papua, Indonesia, using cluster random sampling. Data were recorded using a standardized questionnaire. Blood samples were collected for haemoglobin measurement. Plasmodium parasitaemia was determined by blood film microscopy and PCR. Between April and July 2013, 800 households and 2,830 individuals were surveyed. Peripheral parasitaemia was detected in 37.7% (968/2,567) of individuals, 36.8% (357) of whom were identified by blood film examination. Overall the prevalence of P. falciparum parasitaemia was 15.4% (396/2567) and that of P. vivax 18.3% (471/2567). In parasitaemic individuals, submicroscopic infection was significantly more likely in adults (adjusted odds ratio (AOR): 3.82 [95%CI: 2.49-5.86], p<0.001) compared to children, females (AOR = 1.41 [1.07-1.86], p = 0.013), individuals not sleeping under a bednet (AOR = 1.4 [1.0-1.8], p = 0.035), and being afebrile (AOR = 3.2 [1.49-6.93], p = 0.003). The risk of anaemia (according to WHO guidelines) was 32.8% and significantly increased in those with asymptomatic parasitaemia (AOR 2.9 [95% 2.1-4.0], p = 0.007), and submicroscopic P. falciparum infections (AOR 2.5 [95% 1.7-3.6], p = 0.002). Asymptomatic and submicroscopic infections in this area co-endemic for P. falciparum and P. vivax constitute two thirds of detectable parasitaemia and are associated with a high risk of anaemia. Novel public health strategies are needed to detect and eliminate these parasite reservoirs, for the benefit both of the patient and the community. |
| first_indexed | 2024-12-20T06:45:42Z |
| format | Article |
| id | doaj.art-1acb34e9e6084cd5921389eb616bd687 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T06:45:42Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1acb34e9e6084cd5921389eb616bd6872022-12-21T19:49:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016534010.1371/journal.pone.0165340Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia.Zuleima PavaFaustina H BurdamIrene HandayuniLeily TriantyRetno A S UtamiYusrifar Kharisma TirtaEnny KenangalemDaniel LampahAndreas KusumaGrennady WirjanataSteven KhoJulie A SimpsonSarah AuburnNicholas M DouglasRintis NoviyantiNicholas M AnsteyJeanne R PoespoprodjoJutta MarfurtRic N PriceSubmicroscopic Plasmodium infections are an important parasite reservoir, but their clinical relevance is poorly defined. A cross-sectional household survey was conducted in southern Papua, Indonesia, using cluster random sampling. Data were recorded using a standardized questionnaire. Blood samples were collected for haemoglobin measurement. Plasmodium parasitaemia was determined by blood film microscopy and PCR. Between April and July 2013, 800 households and 2,830 individuals were surveyed. Peripheral parasitaemia was detected in 37.7% (968/2,567) of individuals, 36.8% (357) of whom were identified by blood film examination. Overall the prevalence of P. falciparum parasitaemia was 15.4% (396/2567) and that of P. vivax 18.3% (471/2567). In parasitaemic individuals, submicroscopic infection was significantly more likely in adults (adjusted odds ratio (AOR): 3.82 [95%CI: 2.49-5.86], p<0.001) compared to children, females (AOR = 1.41 [1.07-1.86], p = 0.013), individuals not sleeping under a bednet (AOR = 1.4 [1.0-1.8], p = 0.035), and being afebrile (AOR = 3.2 [1.49-6.93], p = 0.003). The risk of anaemia (according to WHO guidelines) was 32.8% and significantly increased in those with asymptomatic parasitaemia (AOR 2.9 [95% 2.1-4.0], p = 0.007), and submicroscopic P. falciparum infections (AOR 2.5 [95% 1.7-3.6], p = 0.002). Asymptomatic and submicroscopic infections in this area co-endemic for P. falciparum and P. vivax constitute two thirds of detectable parasitaemia and are associated with a high risk of anaemia. Novel public health strategies are needed to detect and eliminate these parasite reservoirs, for the benefit both of the patient and the community.http://europepmc.org/articles/PMC5082812?pdf=render |
| spellingShingle | Zuleima Pava Faustina H Burdam Irene Handayuni Leily Trianty Retno A S Utami Yusrifar Kharisma Tirta Enny Kenangalem Daniel Lampah Andreas Kusuma Grennady Wirjanata Steven Kho Julie A Simpson Sarah Auburn Nicholas M Douglas Rintis Noviyanti Nicholas M Anstey Jeanne R Poespoprodjo Jutta Marfurt Ric N Price Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. PLoS ONE |
| title | Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. |
| title_full | Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. |
| title_fullStr | Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. |
| title_full_unstemmed | Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. |
| title_short | Submicroscopic and Asymptomatic Plasmodium Parasitaemia Associated with Significant Risk of Anaemia in Papua, Indonesia. |
| title_sort | submicroscopic and asymptomatic plasmodium parasitaemia associated with significant risk of anaemia in papua indonesia |
| url | http://europepmc.org/articles/PMC5082812?pdf=render |
| work_keys_str_mv | AT zuleimapava submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT faustinahburdam submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT irenehandayuni submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT leilytrianty submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT retnoasutami submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT yusrifarkharismatirta submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT ennykenangalem submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT daniellampah submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT andreaskusuma submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT grennadywirjanata submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT stevenkho submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT julieasimpson submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT sarahauburn submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT nicholasmdouglas submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT rintisnoviyanti submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT nicholasmanstey submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT jeannerpoespoprodjo submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT juttamarfurt submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia AT ricnprice submicroscopicandasymptomaticplasmodiumparasitaemiaassociatedwithsignificantriskofanaemiainpapuaindonesia |