ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice

ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2-/- Mice

Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s during infection in susceptible BALB/c mice that develop a c...

Full description

Bibliographic Details
Main Authors:	Julia J. Reichwald, Frederic Risch, Anna-Lena Neumann, Stefan J. Frohberger, Johanna F. Scheunemann, Benjamin Lenz, Alexandra Ehrens, Wiebke Strutz, Beatrix Schumak, Achim Hoerauf, Marc P. Hübner
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Immunology
Subjects:	ILC2 Litomosoides sigmodontis Rag2-/- microfilariae IL-5 T cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.863663/full

Similar Items

The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
by: Frederic Risch, et al.
Published: (2023-06-01)

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
by: Stefan J. Frohberger, et al.
Published: (2019-05-01)

Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
by: Laura E. Layland, et al.
Published: (2015-07-01)

Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode <i>Litomosoides sigmodontis</i>
by: Johanna F. Scheunemann, et al.
Published: (2023-05-01)

Differential tissular distribution of Litomosoides sigmodontis microfilariae between microfilaremic and amicrofilaremic mice following experimental infection
by: Bouchery T., et al.
Published: (2012-11-01)

Current perspective of new anti-Wolbachial and direct-acting macrofilaricidal drugs as treatment strategies for human filariasis
by: Ehrens, Alexandra, et al.
Published: (2022-03-01)

Co-infection restrains Litomosoides sigmodontis filarial load and plasmodial P. yoelii but not P. chabaudi parasitaemia in mice
by: Karadjian Gregory, et al.
Published: (2014-01-01)

Adoptive Transfer of Immune Cells Into RAG2IL-2Rγ-Deficient Mice During Litomosoides sigmodontis Infection: A Novel Approach to Investigate Filarial-Specific Immune Responses
by: Anna Wiszniewsky, et al.
Published: (2021-11-01)

Editorial: Host immune response and protective immune responses during filarial infections
by: Manuel Ritter, et al.
Published: (2022-12-01)

A key to the Microfilariae of the Genus Litomosoides (Phylum Nematoda), endoparasites from Colombia bats
by: Marinkelle Cornelis J., et al.
Published: (1999-11-01)

Repeated sensitization of mice with microfilariae of Litomosoides sigmodontis induces pulmonary eosinophilia in an IL-33-dependent manner.
by: Benjamin Lenz, et al.
Published: (2024-03-01)

TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection
by: Buerfent, Benedikt C., et al.
Published: (2019-11-01)

Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during Litomosoides sigmodontis filarial infection
by: Estelle Remion, et al.
Published: (2022-10-01)

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
by: Marc P Hübner, et al.
Published: (2019-01-01)

A Combination of Deworming and Prime-Boost Vaccination Regimen Restores Efficacy of Vaccination Against Influenza in Helminth-Infected Mice
by: Nadine Stetter, et al.
Published: (2021-12-01)

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
by: Alexandra Ehrens, et al.
Published: (2020-01-01)

Eosinophils in filarial infections: Inducers of protection or pathology?
by: Alexandra Ehrens, et al.
Published: (2022-10-01)

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.
by: Stefan J Frohberger, et al.
Published: (2020-02-01)

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
by: Marc P Hübner, et al.
Published: (2020-07-01)

Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner
by: Alexandra Ehrens, et al.
Published: (2021-01-01)

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models
by: Marc P. Hübner, et al.
Published: (2020-04-01)

Redescrição de Litomosoides brasiliensis Almeida, 1936 (Nematoda: Filariidae) Parasito de Anoura caudifera (Chiroptera: Phyllostomidae)
by: Mourão Elizabeth D, et al.
Published: (2002-01-01)

Identification and ultrastructural characterization of the Wolbachia symbiont in Litomosoides chagasfilhoi
by: Vanessa Aparecida Chagas-Moutinho, et al.
Published: (2015-02-01)

Litomosoides yutajensis n. sp., first record of this filarial genus in a mormoopid bat
by: Guerrero R., et al.
Published: (2003-09-01)

Litomosa chiropterorum Ortlepp, 1932 (Nematoda: Filarioidea) from a South African miniopterid: redescription, Wolbachia screening and phylogenetic relationships with Litomosoides
by: Junker K., et al.
Published: (2009-03-01)

New morphological data of Litomosoides chagasfilhoi (Nematoda: Filarioidea) parasitizing Nectomys squamipes in Rio de Janeiro, Brazil
by: Luís Cláudio Muniz-Pereira, et al.

The infective larva of Litomosoides yutajensis Guerrero et al., 2003 (Nematoda: Onchocercidae), a Wolbachia-free filaria from bat
by: Guerrero R., et al.
Published: (2006-06-01)

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
by: Marc P Hübner, et al.
Published: (2019-08-01)

Presence of adult Loa loa in the anterior chamber of the eye along with microfilaremia from nonendemic region: A rare presentation from India
by: Varsha Kumari, et al.
Published: (2019-01-01)

Estudo da variação da microfilaremia em cães infestados por Dirofilaria immitis
by: Maria Helena Matiko Akao Larsson, et al.
Published: (1995-06-01)

Examination of type material of two species of Litomosoides (Filarioidea : Onchocercidae), parasites from bats ; taxonomic consequences
by: Bain O., et al.
Published: (2003-09-01)

Recurrent Swelling and Microfilaremia Caused by Dirofilaria repens Infection after Travel to India
by: Lena Huebl, et al.
Published: (2021-06-01)

<i>Litomosoides</i> sp. (Filarioidea: Onchocercidae) Infection in Frugivorous Bats (<i>Artibeus</i> spp.): Pathological Features, Molecular Evidence, and Prevalence
by: Emilio Rendón-Franco, et al.
Published: (2019-05-01)

Epizootiological observations on canine microfilaremia in Gujarat state, India
by: J. R. Patel, et al.
Published: (2018-11-01)

Immunization with L. sigmodontis microfilariae reduces peripheral microfilaraemia after challenge infection by inhibition of filarial embryogenesis.
by: Sebastian Ziewer, et al.
Published: (2012-01-01)

MiRAGDB: A Knowledgebase of RAG Regulators
by: Sagar Sanjiv Desai, et al.
Published: (2022-03-01)

The genome of Litomosoides sigmodontis illuminates the origins of Y chromosomes in filarial nematodes.
by: Lewis Stevens, et al.
Published: (2024-01-01)

The chemokine CXCL12 is essential for the clearance of the filaria Litomosoides sigmodontis in resistant mice.
by: Tiffany Bouchery, et al.
Published: (2012-01-01)

Limited role of mast cells during infection with the parasitic nematode Litomosoides sigmodontis.
by: Lara Christine Linnemann, et al.
Published: (2020-07-01)

Rag-Pickers as Benefactors and Beneficiaries of the Sustainable Development Goals: A Brief Literature Review
by: G Venkatesh
Published: (2023-03-01)