Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model
Abstract Background The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal mo...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s12906-017-1834-9 |
| _version_ | 1828424418808823808 |
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| author | Yan Jiang Yan Lin Yi-Juan Hu Xiao-Jun Song Hong-Hua Pan Hong-Jian Zhang |
| author_facet | Yan Jiang Yan Lin Yi-Juan Hu Xiao-Jun Song Hong-Hua Pan Hong-Jian Zhang |
| author_sort | Yan Jiang |
| collection | DOAJ |
| description | Abstract Background The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. Methods G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. Results G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. Conclusions The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis. |
| first_indexed | 2024-12-10T16:17:48Z |
| format | Article |
| id | doaj.art-1accea96e4cb4a6da2051004a2003b8f |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-10T16:17:48Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-1accea96e4cb4a6da2051004a2003b8f2022-12-22T01:41:55ZengBMCBMC Complementary and Alternative Medicine1472-68822017-06-0117111010.1186/s12906-017-1834-9Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal modelYan Jiang0Yan Lin1Yi-Juan Hu2Xiao-Jun Song3Hong-Hua Pan4Hong-Jian Zhang5Dispensary of Traditional Chinese Medicine, Hangzhou First People’s HospitalDepartment of Pharmacy, Tongde Hospital of Zhejiang ProvinceKey Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese MedicineDispensary of Traditional Chinese Medicine, Hangzhou First People’s HospitalDepartment of Pharmacy, Tongde Hospital of Zhejiang ProvinceKey Laboratory of Research and Development of Chinese Medicine of Zhejiang Province, Zhejiang Academy of Traditional Chinese MedicineAbstract Background The Gnaphalium pensylvanicum willd. is used in China as a folk medicine to treat anti-inflammatory, cough and rheumatism arthritis. The aim of this study was to evaluate the potential of the extract of G. pensylvanicum to treat hyperuricemia and acute gouty arthritis in animal model. Methods G. pensylvanicum extract was evaluated in an experimental model with potassium oxonate (PO) induced hyperuricemia in mice which was used to evaluate anti-hyperuricemia activity and xanthine oxidase (XO) inhibition. Therapies for acute gouty arthritis was also investigated on monosodium urate (MSU) crystal induced paw edema model. Results G. pensylvanicum extract showed activity in reducing serum uric acid (Sur) through effect renal glucose transporter 9 (GLUT9), organic anion transporter 1 (OAT1) and urate transporter 1 (URAT1) mainly and inhibited XO activity in vivo of mice with PO induced hyperuricemia. The extract of G. pensylvanicum also showed significant anti-inflammatory activity and reduced the paw swelling on MSU crystal-induced paw edema model. Meanwhile, 13 caffeoylquinic acid derivatives and 1 flavone were identified by UPLC-ESI-MS/MS as the main active component of G. pensylvanicum. Conclusions The extract of G. pensylvanicum showed significant effect on evaluated models and therefore may be active agents for the treatment of hyperuricemia and acute gouty arthritis.http://link.springer.com/article/10.1186/s12906-017-1834-9Gnaphalium pensylvanicum Willd.Caffeoylquinic acid derivativesHyperuricemiaAcute gouty arthritisXanthine oxidasePro-inflammatory cytokines |
| spellingShingle | Yan Jiang Yan Lin Yi-Juan Hu Xiao-Jun Song Hong-Hua Pan Hong-Jian Zhang Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model BMC Complementary and Alternative Medicine Gnaphalium pensylvanicum Willd. Caffeoylquinic acid derivatives Hyperuricemia Acute gouty arthritis Xanthine oxidase Pro-inflammatory cytokines |
| title | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model |
| title_full | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model |
| title_fullStr | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model |
| title_full_unstemmed | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model |
| title_short | Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model |
| title_sort | caffeoylquinic acid derivatives rich extract from gnaphalium pensylvanicum willd ameliorates hyperuricemia and acute gouty arthritis in animal model |
| topic | Gnaphalium pensylvanicum Willd. Caffeoylquinic acid derivatives Hyperuricemia Acute gouty arthritis Xanthine oxidase Pro-inflammatory cytokines |
| url | http://link.springer.com/article/10.1186/s12906-017-1834-9 |
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