Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features
Abstract Background Ovarian neuroendocrine carcinoma (O-NEC) is a relatively uncommon neoplasm, and the current knowledge regarding its diagnosis and management is limited. In this series, our objective was to provide an overview of the clinicopathological characteristics of the disease by analyzing...
| Glavni autori: | , , , , , , , |
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| Format: | Članak |
| Jezik: | English |
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BMC
2023-11-01
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| Serija: | BMC Women's Health |
| Teme: | |
| Online pristup: | https://doi.org/10.1186/s12905-023-02722-4 |
| _version_ | 1827708578691022848 |
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| author | Bao-Jie Feng Tian-Hua Li Yue-Hong Li Jing-Xuan Feng Jun Zhang Jun-Ying Ma Yan-Wei Wang Su-Shuang Lu |
| author_facet | Bao-Jie Feng Tian-Hua Li Yue-Hong Li Jing-Xuan Feng Jun Zhang Jun-Ying Ma Yan-Wei Wang Su-Shuang Lu |
| author_sort | Bao-Jie Feng |
| collection | DOAJ |
| description | Abstract Background Ovarian neuroendocrine carcinoma (O-NEC) is a relatively uncommon neoplasm, and the current knowledge regarding its diagnosis and management is limited. In this series, our objective was to provide an overview of the clinicopathological characteristics of the disease by analyzing clinical case data to establish a theoretical foundation for the diagnosis and management of O-NEC. Case presentation We included three patients in the present case series, all of whom were diagnosed with primary O-NEC based on pathomorphological observation and immunohistochemistry. Patient 1 was a 62-year-old patient diagnosed with small cell carcinoma (SCC) of the pulmonary type. Post-surgery, the patient was diagnosed with stage II SCC of the ovary and underwent standardized chemotherapy; however, imaging examinations conducted at the 16-month follow-up revealed the existence of lymph node metastasis. Unfortunately, she passed away 21 months after the surgery. The other two patients were diagnosed with carcinoid tumors, one at age 39 and the other at age 71. Post-surgery, patient 2 was diagnosed with a carcinoid in the left ovary, whereas patient 3 was diagnosed with a carcinoid in her right ovary based on clinical evaluation. Neither of the cases received adjuvant therapy following surgery; however, they have both survived for 9 and 10 years, respectively, as of date. Conclusion Primary O-NECs are rare and of diverse histological types, each of which has its own unique biological features and prognosis. SCC is a neoplasm characterized by high malignancy and a poor prognosis, whereas carcinoid tumors are of lesser malignancy and have a more favorable prognosis. |
| first_indexed | 2024-03-10T17:07:31Z |
| format | Article |
| id | doaj.art-1ace317413db473cbeb755e8ea0635c8 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-10T17:07:31Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-1ace317413db473cbeb755e8ea0635c82023-11-20T10:46:06ZengBMCBMC Women's Health1472-68742023-11-012311810.1186/s12905-023-02722-4Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological featuresBao-Jie Feng0Tian-Hua Li1Yue-Hong Li2Jing-Xuan Feng3Jun Zhang4Jun-Ying Ma5Yan-Wei Wang6Su-Shuang Lu7Department of Gynecology, the Fourth Hospital of Hebei Medical UniversityDepartment of Gynecology, the Fourth Hospital of Hebei Medical UniversityDepartment of Pathology, The Second Hospital of Hebei Medical UniversityDepartment of Clinical Laboratory, The Second Hospital of Hebei Medical UniversityDepartment of Gynecology, the Fourth Hospital of Hebei Medical UniversityDepartment of Gynecology, the Fourth Hospital of Hebei Medical UniversityDepartment of Gynecology, the Fourth Hospital of Hebei Medical UniversityDepartment of Gynecology, The First Hospital of Hebei Medical UniversityAbstract Background Ovarian neuroendocrine carcinoma (O-NEC) is a relatively uncommon neoplasm, and the current knowledge regarding its diagnosis and management is limited. In this series, our objective was to provide an overview of the clinicopathological characteristics of the disease by analyzing clinical case data to establish a theoretical foundation for the diagnosis and management of O-NEC. Case presentation We included three patients in the present case series, all of whom were diagnosed with primary O-NEC based on pathomorphological observation and immunohistochemistry. Patient 1 was a 62-year-old patient diagnosed with small cell carcinoma (SCC) of the pulmonary type. Post-surgery, the patient was diagnosed with stage II SCC of the ovary and underwent standardized chemotherapy; however, imaging examinations conducted at the 16-month follow-up revealed the existence of lymph node metastasis. Unfortunately, she passed away 21 months after the surgery. The other two patients were diagnosed with carcinoid tumors, one at age 39 and the other at age 71. Post-surgery, patient 2 was diagnosed with a carcinoid in the left ovary, whereas patient 3 was diagnosed with a carcinoid in her right ovary based on clinical evaluation. Neither of the cases received adjuvant therapy following surgery; however, they have both survived for 9 and 10 years, respectively, as of date. Conclusion Primary O-NECs are rare and of diverse histological types, each of which has its own unique biological features and prognosis. SCC is a neoplasm characterized by high malignancy and a poor prognosis, whereas carcinoid tumors are of lesser malignancy and have a more favorable prognosis.https://doi.org/10.1186/s12905-023-02722-4ImmunohistochemistryNeuroendocrine carcinomaOvaryPathological characteristicsPrognosis |
| spellingShingle | Bao-Jie Feng Tian-Hua Li Yue-Hong Li Jing-Xuan Feng Jun Zhang Jun-Ying Ma Yan-Wei Wang Su-Shuang Lu Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features BMC Women's Health Immunohistochemistry Neuroendocrine carcinoma Ovary Pathological characteristics Prognosis |
| title | Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features |
| title_full | Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features |
| title_fullStr | Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features |
| title_full_unstemmed | Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features |
| title_short | Case series of ovarian neuroendocrine carcinoma: overview of clinicopathological features |
| title_sort | case series of ovarian neuroendocrine carcinoma overview of clinicopathological features |
| topic | Immunohistochemistry Neuroendocrine carcinoma Ovary Pathological characteristics Prognosis |
| url | https://doi.org/10.1186/s12905-023-02722-4 |
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