Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment

Combinations of Radiotherapy with Vaccination and Immune Checkpoint Inhibition Differently Affect Primary and Abscopal Tumor Growth and the Tumor Microenvironment

Radiotherapy (RT) is known to have immune-modulatory properties. We hypothesized that RT and inactivated whole tumor cell vaccines generated with high hydrostatic pressure (HHP) synergize to retard the tumor growth which can be additionally improved with anti-PD-1 treatment. In abscopal tumor models...

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Bibliographic Details
Main Authors: Michael Rückert, Lisa Deloch, Benjamin Frey, Eberhard Schlücker, Rainer Fietkau, Udo S. Gaipl
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
radiotherapy
vaccination
high hydrostatic pressure
immune checkpoint inhibition
abscopal effect
tumor-infiltrating immune cells
Online Access:https://www.mdpi.com/2072-6694/13/4/714

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