Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer

Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy. The mammary gland seems a relatively straightforward organ with stromal cells and basal- and luminal- epithelial cell types. I...

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Bibliographic Details
Main Authors: Alexandr Samocha, Hanna Doh, Kai Kessenbrock, Jeroen P. Roose
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
mammary gland
breast cancer
cell fate
heterogeneity
3D cultures
organoids
signaling
single-cell RNAseq
Online Access:https://www.mdpi.com/2072-6694/11/10/1423

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