Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan
<i>Background and Objectives</i>: Drug-induced esophageal ulcer is caused by focal drug stimulation. It may occur in adults and children. Limited research is available in pediatric patients with drug-induced esophageal ulcer; therefore, we designed this study to determine the characteris...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/12/1286 |
| _version_ | 1797502561388855296 |
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| author | Shu-Wei Hu An-Chyi Chen Shu-Fen Wu |
| author_facet | Shu-Wei Hu An-Chyi Chen Shu-Fen Wu |
| author_sort | Shu-Wei Hu |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Drug-induced esophageal ulcer is caused by focal drug stimulation. It may occur in adults and children. Limited research is available in pediatric patients with drug-induced esophageal ulcer; therefore, we designed this study to determine the characteristics of this disease in this population. <i>Materials and Methods</i>: Thirty-two pediatric patients diagnosed with drug-induced esophageal ulcers from a hospital database of upper gastrointestinal tract endoscopies were included. After treatment, patients were followed for 2 months after upper gastrointestinal endoscopy. <i>Results</i>: Female patients were predominant (56.2%/43.8%). The mean age of patients was 15.6 years (median, 16 years; interquartile range, 2 years). Doxycycline was administered in most cases (56.3%); other drugs were dicloxacillin, amoxicillin, clindamycin, L-arginine, and nonsteroidal anti-inflammatory drugs. Doxycycline was associated with kissing ulcers. Esophageal ulcers induced by nonsteroidal anti-inflammatory drugs were more often associated with gastric or duodenal ulcers. The most common location was the middle-third of the esophagus (78.1%). Patients were treated with proton pump inhibitors, sucralfate, or H2-blockers. The mean duration for which symptoms lasted was 9.2 days. No esophageal stricture was found in 24 patients who were followed for 2 months after upper gastrointestinal endoscopy. <i>Conclusions</i>: The authors suggest informing patients to take medicine with enough water (approximately 100 mL) and enough time (15–30 min) before recumbency, especially high-risk drugs, such as doxycycline or nonsteroidal anti-inflammatory drugs. |
| first_indexed | 2024-03-10T03:36:51Z |
| format | Article |
| id | doaj.art-1acf1fb86247421db75e3223d606085c |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T03:36:51Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-1acf1fb86247421db75e3223d606085c2023-11-23T09:27:51ZengMDPI AGMedicina1010-660X1648-91442021-11-015712128610.3390/medicina57121286Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central TaiwanShu-Wei Hu0An-Chyi Chen1Shu-Fen Wu2Department of Pediatrics, Tungs’ Taichung MetroHarbor Hospital, No. 699, Sec. 8, Taiwan Blvd., Wuqi Dist., Taichung City 435403, TaiwanDivision of Pediatric Hepatology and Gastroenterology, China Medical University Children’s Hospital, China Medical University, No. 2, Yude Rd., North Dist., Taichung City 404327, TaiwanDivision of Pediatric Hepatology and Gastroenterology, China Medical University Children’s Hospital, China Medical University, No. 2, Yude Rd., North Dist., Taichung City 404327, Taiwan<i>Background and Objectives</i>: Drug-induced esophageal ulcer is caused by focal drug stimulation. It may occur in adults and children. Limited research is available in pediatric patients with drug-induced esophageal ulcer; therefore, we designed this study to determine the characteristics of this disease in this population. <i>Materials and Methods</i>: Thirty-two pediatric patients diagnosed with drug-induced esophageal ulcers from a hospital database of upper gastrointestinal tract endoscopies were included. After treatment, patients were followed for 2 months after upper gastrointestinal endoscopy. <i>Results</i>: Female patients were predominant (56.2%/43.8%). The mean age of patients was 15.6 years (median, 16 years; interquartile range, 2 years). Doxycycline was administered in most cases (56.3%); other drugs were dicloxacillin, amoxicillin, clindamycin, L-arginine, and nonsteroidal anti-inflammatory drugs. Doxycycline was associated with kissing ulcers. Esophageal ulcers induced by nonsteroidal anti-inflammatory drugs were more often associated with gastric or duodenal ulcers. The most common location was the middle-third of the esophagus (78.1%). Patients were treated with proton pump inhibitors, sucralfate, or H2-blockers. The mean duration for which symptoms lasted was 9.2 days. No esophageal stricture was found in 24 patients who were followed for 2 months after upper gastrointestinal endoscopy. <i>Conclusions</i>: The authors suggest informing patients to take medicine with enough water (approximately 100 mL) and enough time (15–30 min) before recumbency, especially high-risk drugs, such as doxycycline or nonsteroidal anti-inflammatory drugs.https://www.mdpi.com/1648-9144/57/12/1286adolescentdrug-induced esophagitisesophageal ulcerendoscopymanagement |
| spellingShingle | Shu-Wei Hu An-Chyi Chen Shu-Fen Wu Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan Medicina adolescent drug-induced esophagitis esophageal ulcer endoscopy management |
| title | Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan |
| title_full | Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan |
| title_fullStr | Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan |
| title_full_unstemmed | Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan |
| title_short | Drug-Induced Esophageal Ulcer in Adolescent Population: Experience at a Single Medical Center in Central Taiwan |
| title_sort | drug induced esophageal ulcer in adolescent population experience at a single medical center in central taiwan |
| topic | adolescent drug-induced esophagitis esophageal ulcer endoscopy management |
| url | https://www.mdpi.com/1648-9144/57/12/1286 |
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