An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report
Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woma...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2022-10-01
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| Series: | Case Reports in Nephrology and Dialysis |
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| Online Access: | https://www.karger.com/Article/FullText/527194 |
| _version_ | 1811307622009143296 |
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| author | Luiz Henrique Lélis Miranda Débora Nóbrega de Lima Marclébio Manuel Coêlho Dourado |
| author_facet | Luiz Henrique Lélis Miranda Débora Nóbrega de Lima Marclébio Manuel Coêlho Dourado |
| author_sort | Luiz Henrique Lélis Miranda |
| collection | DOAJ |
| description | Exercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with intense muscle pain in the ankles, dyspnea, and choluria hours after strenuous physical exercise during a practical test. She sought emergent care the next day, where serum creatinine was measured at 2.4 mg/dL (baseline 1.0 mg/dL) and creatine phosphokinase at 118,000 U/L. She was previously healthy, without regular use of any medication, and habitually sedentary except in training, with no personal or family history of blood or muscle diseases. She was admitted without hemodialysis and discharged after 2 weeks. At 3 months, she had normalization of creatine phosphokinase and creatinine. As an outpatient, other tests were requested. Hemoglobin (Hb) electrophoresis revealed HbA1 of 57.8%, HbA2 of 3.1%, HbF of 0.3%, and HbS of 38.8%, which were compatible with SCT. Evaluation for SCT should be considered in cases of exercise-induced rhabdomyolysis, especially in young, healthy patients. |
| first_indexed | 2024-04-13T09:08:01Z |
| format | Article |
| id | doaj.art-1acf479e3d9449ec88045797db034012 |
| institution | Directory Open Access Journal |
| issn | 2296-9705 |
| language | English |
| last_indexed | 2024-04-13T09:08:01Z |
| publishDate | 2022-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Nephrology and Dialysis |
| spelling | doaj.art-1acf479e3d9449ec88045797db0340122022-12-22T02:52:57ZengKarger PublishersCase Reports in Nephrology and Dialysis2296-97052022-10-0112319320010.1159/000527194527194An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case ReportLuiz Henrique Lélis Miranda0Débora Nóbrega de Lima1Marclébio Manuel Coêlho Dourado2Division of Internal Medicine, Center of Medical Science (CCM), Federal University of Pernambuco, Recife-PE, BrazilDivision of Internal Medicine, Center of Medical Science (CCM), Federal University of Pernambuco, Recife-PE, BrazilAdjunct Professor, Division of Nephrology, Center of Medical Science (CCM), Federal University of Pernambuco, Recife-PE, BrazilExercise-induced rhabdomyolysis refers to the breakdown of striated muscle, which releases intracellular elements into the bloodstream due to heavy physical activity. In rare instances, this condition may be the first clinical manifestation of sickle cell trait (SCT). We report on a 31-year-old woman with post-infectious fatigue who, after suffering mild COVID-19 symptoms 3 weeks prior, presented with intense muscle pain in the ankles, dyspnea, and choluria hours after strenuous physical exercise during a practical test. She sought emergent care the next day, where serum creatinine was measured at 2.4 mg/dL (baseline 1.0 mg/dL) and creatine phosphokinase at 118,000 U/L. She was previously healthy, without regular use of any medication, and habitually sedentary except in training, with no personal or family history of blood or muscle diseases. She was admitted without hemodialysis and discharged after 2 weeks. At 3 months, she had normalization of creatine phosphokinase and creatinine. As an outpatient, other tests were requested. Hemoglobin (Hb) electrophoresis revealed HbA1 of 57.8%, HbA2 of 3.1%, HbF of 0.3%, and HbS of 38.8%, which were compatible with SCT. Evaluation for SCT should be considered in cases of exercise-induced rhabdomyolysis, especially in young, healthy patients.https://www.karger.com/Article/FullText/527194sickle cell traitrhabdomyolysisacute kidney injurysars-cov-2 |
| spellingShingle | Luiz Henrique Lélis Miranda Débora Nóbrega de Lima Marclébio Manuel Coêlho Dourado An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report Case Reports in Nephrology and Dialysis sickle cell trait rhabdomyolysis acute kidney injury sars-cov-2 |
| title | An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report |
| title_full | An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report |
| title_fullStr | An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report |
| title_full_unstemmed | An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report |
| title_short | An Unusual Presentation of Rhabdomyolysis and Acute Kidney Injury after Physical Activity: A Case Report |
| title_sort | unusual presentation of rhabdomyolysis and acute kidney injury after physical activity a case report |
| topic | sickle cell trait rhabdomyolysis acute kidney injury sars-cov-2 |
| url | https://www.karger.com/Article/FullText/527194 |
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