Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data
Background: Cigarette smoking is believed to accelerate age-related neurodegeneration. Despite significant sex differences in both smoking behaviors and brain structures, the active literature is equivocal in parsing out a sex difference in smoking-associated brain structural changes. Objective: The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/8/1164 |
| _version_ | 1797585293369409536 |
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| author | Xiaofei Chen Riley Cook Francesca M. Filbey Hang Nguyen Roderick McColl Haekyung Jeon-Slaughter |
| author_facet | Xiaofei Chen Riley Cook Francesca M. Filbey Hang Nguyen Roderick McColl Haekyung Jeon-Slaughter |
| author_sort | Xiaofei Chen |
| collection | DOAJ |
| description | Background: Cigarette smoking is believed to accelerate age-related neurodegeneration. Despite significant sex differences in both smoking behaviors and brain structures, the active literature is equivocal in parsing out a sex difference in smoking-associated brain structural changes. Objective: The current study examined subcortical and lateral ventricle gray matter (GM) volume differences among smokers, active, past, and never-smokers, stratified by sex. Methods: The current study data included 1959 Dallas Heart Study (DHS) participants with valid brain imaging data. Stratified by gender, multiple-group comparisons of three cigarette-smoking groups were conducted to test whether there is any cigarette-smoking group differences in GM volumes of the selected regions of interest (ROIs). Results: The largest subcortical GM volumetric loss and enlargement of the lateral ventricle were observed among past smokers for both females and males. However, these observed group differences in GM volumetric changes were statistically significant only among males after adjusting for age and intracranial volumes. Conclusions: The study findings suggest a sex difference in lifetime-smoking-associated GM volumetric changes, even after controlling for aging and intracranial volumes. |
| first_indexed | 2024-03-11T00:05:08Z |
| format | Article |
| id | doaj.art-1ad1359866164aab94d2e3821911ac4c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T00:05:08Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-1ad1359866164aab94d2e3821911ac4c2023-11-19T00:26:39ZengMDPI AGBrain Sciences2076-34252023-08-01138116410.3390/brainsci13081164Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative DataXiaofei Chen0Riley Cook1Francesca M. Filbey2Hang Nguyen3Roderick McColl4Haekyung Jeon-Slaughter5Department of Statistics and Data Science, Southern Methodist University, Dallas, TX 75205, USAVA North Texas Health Care Service, Dallas, TX 75216, USASchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX 75080, USADepartment of Statistics and Data Science, Southern Methodist University, Dallas, TX 75205, USADepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USAVA North Texas Health Care Service, Dallas, TX 75216, USABackground: Cigarette smoking is believed to accelerate age-related neurodegeneration. Despite significant sex differences in both smoking behaviors and brain structures, the active literature is equivocal in parsing out a sex difference in smoking-associated brain structural changes. Objective: The current study examined subcortical and lateral ventricle gray matter (GM) volume differences among smokers, active, past, and never-smokers, stratified by sex. Methods: The current study data included 1959 Dallas Heart Study (DHS) participants with valid brain imaging data. Stratified by gender, multiple-group comparisons of three cigarette-smoking groups were conducted to test whether there is any cigarette-smoking group differences in GM volumes of the selected regions of interest (ROIs). Results: The largest subcortical GM volumetric loss and enlargement of the lateral ventricle were observed among past smokers for both females and males. However, these observed group differences in GM volumetric changes were statistically significant only among males after adjusting for age and intracranial volumes. Conclusions: The study findings suggest a sex difference in lifetime-smoking-associated GM volumetric changes, even after controlling for aging and intracranial volumes.https://www.mdpi.com/2076-3425/13/8/1164cigarette smokingbrain volumessexsubcortical regionlateral ventricle |
| spellingShingle | Xiaofei Chen Riley Cook Francesca M. Filbey Hang Nguyen Roderick McColl Haekyung Jeon-Slaughter Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data Brain Sciences cigarette smoking brain volumes sex subcortical region lateral ventricle |
| title | Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data |
| title_full | Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data |
| title_fullStr | Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data |
| title_full_unstemmed | Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data |
| title_short | Sex Difference in Cigarette-Smoking Status and Its Association with Brain Volumes Using Large-Scale Community-Representative Data |
| title_sort | sex difference in cigarette smoking status and its association with brain volumes using large scale community representative data |
| topic | cigarette smoking brain volumes sex subcortical region lateral ventricle |
| url | https://www.mdpi.com/2076-3425/13/8/1164 |
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