Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial
Intestinal integrity prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system. Damage in intestinal integrity may cause mild to serious health issues, such as inflammation, gastrointestinal disorders, neurological diseases,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/3/268 |
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| author | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Narissara Lailerd Sasithorn Sirilun Suchanat Khongtan Pranom Fukngoen Sartjin Peerajan Manee Saelee Khontaros Chaiyasut Periyanaina Kesika Phakkharawat Sittiprapaporn |
| author_facet | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Narissara Lailerd Sasithorn Sirilun Suchanat Khongtan Pranom Fukngoen Sartjin Peerajan Manee Saelee Khontaros Chaiyasut Periyanaina Kesika Phakkharawat Sittiprapaporn |
| author_sort | Chaiyavat Chaiyasut |
| collection | DOAJ |
| description | Intestinal integrity prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system. Damage in intestinal integrity may cause mild to serious health issues, such as inflammation, gastrointestinal disorders, neurological diseases, and neurodegenerative disorders. Thus, maintaining a healthy intestinal barrier function is essential to sustain health. Probiotics are known for their ability to protect and restore intestinal permeability in vitro and in vivo. The multi-strain probiotics are more efficient than that of a single strain in terms of their protective efficacy. Therefore, the present study was planned and implemented to study the supplementation of probiotic mix (<i>Lactobacillus paracasei</i> HII01, <i>Bifidobacterium</i><i>breve</i>, and <i>Bifidobacterium longum</i>) on intestinal permeability, lipid profile, obesity index and metabolic biomarkers in elderly Thai subjects. The results revealed that the supplementation of studied probiotics improved the intestinal barrier function (up to 48%), significantly increasing the high-density lipoprotein (HDL)-cholesterol. Moreover, the intervention improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects. The current study strongly recommends further extended research to confirm the beneficial effect of probiotics, which may pave the way to formulate probiotic-based health supplements to adjuvant the treatment of several metabolic diseases. |
| first_indexed | 2024-03-09T23:54:14Z |
| format | Article |
| id | doaj.art-1ad18ab6c6af4738be9e6e0422de2e93 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T23:54:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-1ad18ab6c6af4738be9e6e0422de2e932023-11-23T16:28:07ZengMDPI AGFoods2304-81582022-01-0111326810.3390/foods11030268Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled TrialChaiyavat Chaiyasut0Bhagavathi Sundaram Sivamaruthi1Narissara Lailerd2Sasithorn Sirilun3Suchanat Khongtan4Pranom Fukngoen5Sartjin Peerajan6Manee Saelee7Khontaros Chaiyasut8Periyanaina Kesika9Phakkharawat Sittiprapaporn10Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandHealth Innovation Institute, Chiang Mai 50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandInstitute of Research and Development, Chiang Mai Rajabhat University, Chiang Mai 50300, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandNeuropsychological Research Laboratory, Department of Anti-Aging and Regenerative Science, School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok 11120, ThailandIntestinal integrity prevents the diffusion of allergens, toxins, and pathogens from the gastrointestinal lumen into the tissue and the circulatory system. Damage in intestinal integrity may cause mild to serious health issues, such as inflammation, gastrointestinal disorders, neurological diseases, and neurodegenerative disorders. Thus, maintaining a healthy intestinal barrier function is essential to sustain health. Probiotics are known for their ability to protect and restore intestinal permeability in vitro and in vivo. The multi-strain probiotics are more efficient than that of a single strain in terms of their protective efficacy. Therefore, the present study was planned and implemented to study the supplementation of probiotic mix (<i>Lactobacillus paracasei</i> HII01, <i>Bifidobacterium</i><i>breve</i>, and <i>Bifidobacterium longum</i>) on intestinal permeability, lipid profile, obesity index and metabolic biomarkers in elderly Thai subjects. The results revealed that the supplementation of studied probiotics improved the intestinal barrier function (up to 48%), significantly increasing the high-density lipoprotein (HDL)-cholesterol. Moreover, the intervention improved obesity-related anthropometric biomarkers and short-chain fatty acid levels in human subjects. The current study strongly recommends further extended research to confirm the beneficial effect of probiotics, which may pave the way to formulate probiotic-based health supplements to adjuvant the treatment of several metabolic diseases.https://www.mdpi.com/2304-8158/11/3/268probiotics<i>Lactobacillus</i><i>Bifidobacterium</i>intestinal permeabilitycholesterol |
| spellingShingle | Chaiyavat Chaiyasut Bhagavathi Sundaram Sivamaruthi Narissara Lailerd Sasithorn Sirilun Suchanat Khongtan Pranom Fukngoen Sartjin Peerajan Manee Saelee Khontaros Chaiyasut Periyanaina Kesika Phakkharawat Sittiprapaporn Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial Foods probiotics <i>Lactobacillus</i> <i>Bifidobacterium</i> intestinal permeability cholesterol |
| title | Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial |
| title_full | Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial |
| title_fullStr | Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial |
| title_full_unstemmed | Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial |
| title_short | Probiotics Supplementation Improves Intestinal Permeability, Obesity Index and Metabolic Biomarkers in Elderly Thai Subjects: A Randomized Controlled Trial |
| title_sort | probiotics supplementation improves intestinal permeability obesity index and metabolic biomarkers in elderly thai subjects a randomized controlled trial |
| topic | probiotics <i>Lactobacillus</i> <i>Bifidobacterium</i> intestinal permeability cholesterol |
| url | https://www.mdpi.com/2304-8158/11/3/268 |
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