Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis
ABSTRACT Objective: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening infectious disease. Treatment requires multiple antimicrobial agents used for extended periods of time. The present study sought to evaluate the treatment success rate of bedaquiline-based regimens in MDR-TB patient...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Pneumologia e Tisiologia
2022-05-01
|
| Series: | Jornal Brasileiro de Pneumologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000201200&lng=en&tlng=en |
| _version_ | 1818213503543017472 |
|---|---|
| author | Hossein Hatami Giovanni Sotgiu Narjess Bostanghadiri Sahel Shafiee Dolat Abadi Bita Mesgarpour Hossein Goudarzi Giovanni Battista Migliori Mohammad Javad Nasiri |
| author_facet | Hossein Hatami Giovanni Sotgiu Narjess Bostanghadiri Sahel Shafiee Dolat Abadi Bita Mesgarpour Hossein Goudarzi Giovanni Battista Migliori Mohammad Javad Nasiri |
| author_sort | Hossein Hatami |
| collection | DOAJ |
| description | ABSTRACT Objective: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening infectious disease. Treatment requires multiple antimicrobial agents used for extended periods of time. The present study sought to evaluate the treatment success rate of bedaquiline-based regimens in MDR-TB patients. Methods: This was a systematic review and meta-analysis of studies published up to March 15, 2021. The pooled treatment success rates and 95% CIs were assessed with the fixed-effect model or the random-effects model. Values of p < 0.05 were considered significant for publication bias. Results: A total of 2,679 articles were retrieved by database searching. Of those, 29 met the inclusion criteria. Of those, 25 were observational studies (including a total of 3,536 patients) and 4 were experimental studies (including a total of 440 patients). The pooled treatment success rate was 74.7% (95% CI, 69.8-79.0) in the observational studies and 86.1% (95% CI, 76.8-92.1; p = 0.00; I2 = 75%) in the experimental studies. There was no evidence of publication bias (p > 0.05). Conclusions: In patients with MDR-TB receiving bedaquiline, culture conversion and treatment success rates are high even in cases of extensive resistance. |
| first_indexed | 2024-12-12T06:05:20Z |
| format | Article |
| id | doaj.art-1ad1d08434a84f8381a109cf19ff597d |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-12-12T06:05:20Z |
| publishDate | 2022-05-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-1ad1d08434a84f8381a109cf19ff597d2022-12-22T00:35:17ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562022-05-0148210.36416/1806-3756/e20210384Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysisHossein Hatamihttps://orcid.org/0000-0002-1448-3598Giovanni Sotgiuhttps://orcid.org/0000-0002-1600-4474Narjess Bostanghadirihttps://orcid.org/0000-0002-7343-5289Sahel Shafiee Dolat Abadihttps://orcid.org/0000-0003-4231-844XBita Mesgarpourhttps://orcid.org/0000-0002-4004-8493Hossein Goudarzihttps://orcid.org/0000-0001-8965-8690Giovanni Battista Migliorihttps://orcid.org/0000-0002-2597-574XMohammad Javad Nasirihttps://orcid.org/0000-0002-3279-0671ABSTRACT Objective: Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening infectious disease. Treatment requires multiple antimicrobial agents used for extended periods of time. The present study sought to evaluate the treatment success rate of bedaquiline-based regimens in MDR-TB patients. Methods: This was a systematic review and meta-analysis of studies published up to March 15, 2021. The pooled treatment success rates and 95% CIs were assessed with the fixed-effect model or the random-effects model. Values of p < 0.05 were considered significant for publication bias. Results: A total of 2,679 articles were retrieved by database searching. Of those, 29 met the inclusion criteria. Of those, 25 were observational studies (including a total of 3,536 patients) and 4 were experimental studies (including a total of 440 patients). The pooled treatment success rate was 74.7% (95% CI, 69.8-79.0) in the observational studies and 86.1% (95% CI, 76.8-92.1; p = 0.00; I2 = 75%) in the experimental studies. There was no evidence of publication bias (p > 0.05). Conclusions: In patients with MDR-TB receiving bedaquiline, culture conversion and treatment success rates are high even in cases of extensive resistance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000201200&lng=en&tlng=enTuberculosisDrug resistanceTuberculosis, multidrug-resistantEfficacy |
| spellingShingle | Hossein Hatami Giovanni Sotgiu Narjess Bostanghadiri Sahel Shafiee Dolat Abadi Bita Mesgarpour Hossein Goudarzi Giovanni Battista Migliori Mohammad Javad Nasiri Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis Jornal Brasileiro de Pneumologia Tuberculosis Drug resistance Tuberculosis, multidrug-resistant Efficacy |
| title | Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full | Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_fullStr | Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_full_unstemmed | Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_short | Bedaquiline-containing regimens and multidrug-resistant tuberculosis: a systematic review and meta-analysis |
| title_sort | bedaquiline containing regimens and multidrug resistant tuberculosis a systematic review and meta analysis |
| topic | Tuberculosis Drug resistance Tuberculosis, multidrug-resistant Efficacy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000201200&lng=en&tlng=en |
| work_keys_str_mv | AT hosseinhatami bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT giovannisotgiu bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT narjessbostanghadiri bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT sahelshafieedolatabadi bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT bitamesgarpour bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT hosseingoudarzi bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT giovannibattistamigliori bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis AT mohammadjavadnasiri bedaquilinecontainingregimensandmultidrugresistanttuberculosisasystematicreviewandmetaanalysis |