Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study
An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and bone. Osteocytes, which a...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-08-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X2300052X |
| _version_ | 1797900612045635584 |
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| author | Jonathan Espiritu Sandra Sefa Hanna Ćwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff |
| author_facet | Jonathan Espiritu Sandra Sefa Hanna Ćwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff |
| author_sort | Jonathan Espiritu |
| collection | DOAJ |
| description | An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and bone. Osteocytes, which are housed and communicate through the lacuno-canalicular network (LCN), are integral to bone health and remodelling processes. Therefore, it is essential to examine the framework of the LCN in response to implant materials or surface treatments.Biodegradable materials offer an alternative solution to permanent implants, which may require revision or removal surgeries. Magnesium alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in vivo. To further tailor their degradation capabilities, surface treatments such as plasma electrolytic oxidation (PEO) have demonstrated to slow degradation.For the first time, the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D imaging. In this pilot study, we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the PEO-coating.Utilising synchrotron-based transmission X-ray microscopy, we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep bone. Bone specimens were explanted after 4, 8, and 12 weeks and regions near the implant surface were prepared for imaging. Findings from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the LCN. However, the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance. |
| first_indexed | 2024-04-10T08:48:45Z |
| format | Article |
| id | doaj.art-1ad288db1a57460ab04341b7271dbc50 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-10T08:48:45Z |
| publishDate | 2023-08-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-1ad288db1a57460ab04341b7271dbc502023-02-22T04:32:04ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-08-01261423Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot studyJonathan Espiritu0Sandra Sefa1Hanna Ćwieka2Imke Greving3Silja Flenner4Regine Willumeit-Römer5Jan-Marten Seitz6Berit Zeller-Plumhoff7Syntellix AG, Hannover, Germany; Corresponding author. Syntellix AG, Aegidientorplatz 2a, Hannover, 30159, Germany.Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, GermanyInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, GermanyInstitute of Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, GermanyInstitute of Materials Physics, Helmholtz-Zentrum Hereon, Geesthacht, GermanyInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, GermanySyntellix AG, Hannover, GermanyInstitute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Geesthacht, Germany; Corresponding author. Helmholtz-Zentrum Hereon, Max-Planck-Strasse 1, Geesthacht, 21502, Germany.An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market. A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and bone. Osteocytes, which are housed and communicate through the lacuno-canalicular network (LCN), are integral to bone health and remodelling processes. Therefore, it is essential to examine the framework of the LCN in response to implant materials or surface treatments.Biodegradable materials offer an alternative solution to permanent implants, which may require revision or removal surgeries. Magnesium alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in vivo. To further tailor their degradation capabilities, surface treatments such as plasma electrolytic oxidation (PEO) have demonstrated to slow degradation.For the first time, the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D imaging. In this pilot study, we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the PEO-coating.Utilising synchrotron-based transmission X-ray microscopy, we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep bone. Bone specimens were explanted after 4, 8, and 12 weeks and regions near the implant surface were prepared for imaging. Findings from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the LCN. However, the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance.http://www.sciencedirect.com/science/article/pii/S2452199X2300052XNanotomographyLacuno-canalicular networkBoneMagnesiumBiodegradable implants |
| spellingShingle | Jonathan Espiritu Sandra Sefa Hanna Ćwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study Bioactive Materials Nanotomography Lacuno-canalicular network Bone Magnesium Biodegradable implants |
| title | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study |
| title_full | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study |
| title_fullStr | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study |
| title_full_unstemmed | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study |
| title_short | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study |
| title_sort | detailing the influence of peo coated biodegradable mg based implants on the lacuno canalicular network in sheep bone a pilot study |
| topic | Nanotomography Lacuno-canalicular network Bone Magnesium Biodegradable implants |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X2300052X |
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