LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4

LINC00909 up-regulates pluripotency factors and promotes cancer stemness and metastasis in pancreatic ductal adenocarcinoma by targeting SMAD4

Abstract Background Pancreatic cancer stem cells are crucial for tumorigenesis and cancer metastasis. Presently, long non-coding RNAs were found to be associated with Pancreatic Ductal Adenocarcinoma stemness characteristics but the underlying mechanism is largely known. Here, we aim to explore the...

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Bibliographic Details
Main Authors: Zhenchong Li, Zuyi Ma, Shujie Wang, Qian Yan, Hongkai Zhuang, Zixuan Zhou, Chunsheng Liu, Yubin Chen, Mingqian Han, Zelong Wu, Shanzhou Huang, Qi Zhou, Baohua Hou, Chuanzhao Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Biology Direct
Subjects:
LINC00909
Cancer stemness
Tumor metastasis
Pancreatic ductal adenocarcinoma
SMAD4
Pluripotency factors
Online Access:https://doi.org/10.1186/s13062-024-00463-4

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