A Germline Mutation in the <i>POT1</i> Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer

A Germline Mutation in the <i>POT1</i> Gene Is a Candidate for Familial Non-Medullary Thyroid Cancer

Non-medullary thyroid cancer (NMTC) is a common endocrine malignancy with a genetic basis that has yet to be unequivocally established. In a recent whole-genome sequencing study of five families with occurrence of NMTCs, we shortlisted promising variants with the help of bioinformatics tools. Here,...

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Bibliographic Details
Main Authors: Aayushi Srivastava, Beiping Miao, Diamanto Skopelitou, Varun Kumar, Abhishek Kumar, Nagarajan Paramasivam, Elena Bonora, Kari Hemminki, Asta Försti, Obul Reddy Bandapalli
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
familial non-medullary thyroid cancer
non-syndromic
POT1
shelterin complex
telomere length
germline variant
Online Access:https://www.mdpi.com/2072-6694/12/6/1441

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