New insights into the antifungal activity of Taxus baccata L.
Taxus baccata L., yew, is dioecious, small to medium-sized evergreen tree, native to Europe, Africa and Asia, but it is cultivated worldwide because of its ornamental features. It is long known that all parts of yew (except for aril) are toxic, due to the alkaloid taxine. Nevertheless, some parts of...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2019-06-01
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| Series: | Genetics & Applications |
| Online Access: | http://www.genapp.ba/index.php/genapp/article/view/80 |
| _version_ | 1818481871393128448 |
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| author | Irma Mahmutović-Dizdarević Dalila Žilić Behija Dukić |
| author_facet | Irma Mahmutović-Dizdarević Dalila Žilić Behija Dukić |
| author_sort | Irma Mahmutović-Dizdarević |
| collection | DOAJ |
| description | Taxus baccata L., yew, is dioecious, small to medium-sized evergreen tree, native to Europe, Africa and Asia, but it is cultivated worldwide because of its ornamental features. It is long known that all parts of yew (except for aril) are toxic, due to the alkaloid taxine. Nevertheless, some parts of yew tree can be used to treat cancer and as antimicrobial agents. Unlike its antibacterial properties, antifungal activity of T. baccata is poorly investigated. In this research, antifungal activity of yew methanolic and aqueous extracts was tested against Candida albicans ATCC 10231, Aspergillus brasiliensis ATCC 16404, and Ascosphaera apis MUCL 30769, through the agar well diffusion method. Leaves, bark and reproductive structures extracts were prepared separately for male and female plants. Unlike the aqueous, methanolic extracts caused variable degree of fungal growth inhibition. The strongest inhibition was observed in the activity of the aril extract against A. brasiliensis and C. albicans, with the activity of the male bark extract against A. apis following close. Considering the emerging multidrug resistance in C. albicans, an interesting finding is the inhibition of this species by all tested methanolic extracts, which is significantly stronger in comparison to the inhibition by standard antimycotic solution. According to the available data, male reproductive structures of this species were not tested earlier for their antifungal activity, and our study showed high level of antifungal activity of methanolic microstrobili extract. |
| first_indexed | 2024-12-10T11:40:49Z |
| format | Article |
| id | doaj.art-1ad69027a19b4dce9e22ccbb6924ec6a |
| institution | Directory Open Access Journal |
| issn | 2566-2937 2566-431X |
| language | English |
| last_indexed | 2024-12-10T11:40:49Z |
| publishDate | 2019-06-01 |
| publisher | University of Sarajevo, Institute for Genetic Engineering and Biotechnology |
| record_format | Article |
| series | Genetics & Applications |
| spelling | doaj.art-1ad69027a19b4dce9e22ccbb6924ec6a2022-12-22T01:50:15ZengUniversity of Sarajevo, Institute for Genetic Engineering and BiotechnologyGenetics & Applications2566-29372566-431X2019-06-0131657010.31383/ga.vol3iss1pp65-7080New insights into the antifungal activity of Taxus baccata L.Irma Mahmutović-Dizdarević0Dalila Žilić1Behija Dukić2University of Sarajevo – Faculty of Science, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo – Faculty of Science, Sarajevo, Bosnia and HerzegovinaUniversity of Sarajevo – Faculty of Veterinary Medicine, Sarajevo, Bosnia and HerzegovinaTaxus baccata L., yew, is dioecious, small to medium-sized evergreen tree, native to Europe, Africa and Asia, but it is cultivated worldwide because of its ornamental features. It is long known that all parts of yew (except for aril) are toxic, due to the alkaloid taxine. Nevertheless, some parts of yew tree can be used to treat cancer and as antimicrobial agents. Unlike its antibacterial properties, antifungal activity of T. baccata is poorly investigated. In this research, antifungal activity of yew methanolic and aqueous extracts was tested against Candida albicans ATCC 10231, Aspergillus brasiliensis ATCC 16404, and Ascosphaera apis MUCL 30769, through the agar well diffusion method. Leaves, bark and reproductive structures extracts were prepared separately for male and female plants. Unlike the aqueous, methanolic extracts caused variable degree of fungal growth inhibition. The strongest inhibition was observed in the activity of the aril extract against A. brasiliensis and C. albicans, with the activity of the male bark extract against A. apis following close. Considering the emerging multidrug resistance in C. albicans, an interesting finding is the inhibition of this species by all tested methanolic extracts, which is significantly stronger in comparison to the inhibition by standard antimycotic solution. According to the available data, male reproductive structures of this species were not tested earlier for their antifungal activity, and our study showed high level of antifungal activity of methanolic microstrobili extract.http://www.genapp.ba/index.php/genapp/article/view/80 |
| spellingShingle | Irma Mahmutović-Dizdarević Dalila Žilić Behija Dukić New insights into the antifungal activity of Taxus baccata L. Genetics & Applications |
| title | New insights into the antifungal activity of Taxus baccata L. |
| title_full | New insights into the antifungal activity of Taxus baccata L. |
| title_fullStr | New insights into the antifungal activity of Taxus baccata L. |
| title_full_unstemmed | New insights into the antifungal activity of Taxus baccata L. |
| title_short | New insights into the antifungal activity of Taxus baccata L. |
| title_sort | new insights into the antifungal activity of taxus baccata l |
| url | http://www.genapp.ba/index.php/genapp/article/view/80 |
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