Review of the impact of molecular analysis on the therapy of medulloblastoma
Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124523000268 |
| Summary: | Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated introduction of risk-adjusted therapy. Newer subtyping of MB has the potential to rapidly guide the development of clinical trials that further explore risk-adjusted therapies. This review summarizes recent advances in the molecular characterization of medulloblastoma and evaluates subgroup directed treatment. |
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| ISSN: | 2468-1245 |