Review of the impact of molecular analysis on the therapy of medulloblastoma
Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
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| Series: | Pediatric Hematology Oncology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468124523000268 |
| _version_ | 1797790034166808576 |
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| author | Supriya Sarvode Amar Gajjar |
| author_facet | Supriya Sarvode Amar Gajjar |
| author_sort | Supriya Sarvode |
| collection | DOAJ |
| description | Medulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated introduction of risk-adjusted therapy. Newer subtyping of MB has the potential to rapidly guide the development of clinical trials that further explore risk-adjusted therapies. This review summarizes recent advances in the molecular characterization of medulloblastoma and evaluates subgroup directed treatment. |
| first_indexed | 2024-03-13T01:59:01Z |
| format | Article |
| id | doaj.art-1ad7096428154a66bdbb11acb6245809 |
| institution | Directory Open Access Journal |
| issn | 2468-1245 |
| language | English |
| last_indexed | 2024-03-13T01:59:01Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatric Hematology Oncology Journal |
| spelling | doaj.art-1ad7096428154a66bdbb11acb62458092023-07-02T04:17:04ZengElsevierPediatric Hematology Oncology Journal2468-12452023-06-0182121128Review of the impact of molecular analysis on the therapy of medulloblastomaSupriya Sarvode0Amar Gajjar1Corresponding author.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USADepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USAMedulloblastoma (MB) is a brain tumor composed of distinct molecularly defined subgroups. Recent advances in genomics and transcriptomics have revealed >12 subtypes within the previously identified four subgroups. Molecular classification has improved clinical outcome predictions and facilitated introduction of risk-adjusted therapy. Newer subtyping of MB has the potential to rapidly guide the development of clinical trials that further explore risk-adjusted therapies. This review summarizes recent advances in the molecular characterization of medulloblastoma and evaluates subgroup directed treatment.http://www.sciencedirect.com/science/article/pii/S2468124523000268MedulloblastomaMolecular classificationRisk adapted therapy |
| spellingShingle | Supriya Sarvode Amar Gajjar Review of the impact of molecular analysis on the therapy of medulloblastoma Pediatric Hematology Oncology Journal Medulloblastoma Molecular classification Risk adapted therapy |
| title | Review of the impact of molecular analysis on the therapy of medulloblastoma |
| title_full | Review of the impact of molecular analysis on the therapy of medulloblastoma |
| title_fullStr | Review of the impact of molecular analysis on the therapy of medulloblastoma |
| title_full_unstemmed | Review of the impact of molecular analysis on the therapy of medulloblastoma |
| title_short | Review of the impact of molecular analysis on the therapy of medulloblastoma |
| title_sort | review of the impact of molecular analysis on the therapy of medulloblastoma |
| topic | Medulloblastoma Molecular classification Risk adapted therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2468124523000268 |
| work_keys_str_mv | AT supriyasarvode reviewoftheimpactofmolecularanalysisonthetherapyofmedulloblastoma AT amargajjar reviewoftheimpactofmolecularanalysisonthetherapyofmedulloblastoma |