Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome
Objective:Elevated liver function tests (LFTs) are common in adult Turner syndrome (TS) patients. Data regarding children and adolescents are lacking. To investigate the prevalence of abnormal LFTs in children and adolescents with TS during several years of observation; to evaluate the potential imp...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayincilik
2019-12-01
|
| Series: | JCRPE |
| Subjects: | |
| Online Access: |
http://www.jcrpe.org/archives/archive-detail/article-preview/liver-biochemical-abnormalities-in-adolescent-pati/27600
|
| _version_ | 1797923453547839488 |
|---|---|
| author | Małgorzata Wójcik Anna Ruszała Dominika Januś Jerzy B. Starzyk |
| author_facet | Małgorzata Wójcik Anna Ruszała Dominika Januś Jerzy B. Starzyk |
| author_sort | Małgorzata Wójcik |
| collection | DOAJ |
| description | Objective:Elevated liver function tests (LFTs) are common in adult Turner syndrome (TS) patients. Data regarding children and adolescents are lacking. To investigate the prevalence of abnormal LFTs in children and adolescents with TS during several years of observation; to evaluate the potential impact of increased body mass index (BMI) and sex hormone replacement therapy (HRT) on LFTs.Methods:The analysis included 100 girls with TS, aged 4-16 years, all of whom were receiving recombinant human growth hormone therapy. A longitudinal study was conducted which included 81 patients.Results:Mean BMI-standard deviation (SD) score of the subjects was 0.63 (SD: 1.53). Forty-four were being treated with HRT. Elevated LFTs were found in 34% of the patients overall (32% not receiving HRT vs 36% on HRT). The relative risk of increased LFTs was not higher in obese vs normal weight [odds ratio (OR): 0.2; 95% confidence interval (CI): 0.1-0.36, p=0.38 vs OR: 0.16; 95% CI: 0.08-0.3, p=0.1]. HRT did not increase the risk of abnormal LFTs activity (OR: 0.8; 95% CI: 0.5-1.2, p=0.37 vs OR: 0.7; 95% CI: 0.4-1.1, p=0.27). During the follow-up period (mean±SD=4.31±0.82 years), no patient developed overt liver disease. There was no significant increase nor decrease of abnormal LFT frequency in the subsequent years of follow up.Conclusion:Constantly elevated LFTs in TS are common in children and adolescents with TS. However the causes and clinical significance remain unclear. This study suggests that obesity and HRT do not increase the risk of elevated LFTs. |
| first_indexed | 2024-04-10T14:46:32Z |
| format | Article |
| id | doaj.art-1ad95052708c43fabf56d98ab798bd32 |
| institution | Directory Open Access Journal |
| issn | 1308-5727 1308-5735 |
| language | English |
| last_indexed | 2024-04-10T14:46:32Z |
| publishDate | 2019-12-01 |
| publisher | Galenos Yayincilik |
| record_format | Article |
| series | JCRPE |
| spelling | doaj.art-1ad95052708c43fabf56d98ab798bd322023-02-15T16:07:47ZengGalenos YayincilikJCRPE1308-57271308-57352019-12-0111439539910.4274/jcrpe.galenos.2019.2018.027113049054Liver Biochemical Abnormalities in Adolescent Patients with Turner SyndromeMałgorzata Wójcik0Anna Ruszała1Dominika Januś2Jerzy B. Starzyk3 Jagiellonian University Medical College, Pediatric Institute, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics; Children’s University Hospital, Kraków, Poland Jagiellonian University Medical College, Pediatric Institute, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics; Children’s University Hospital, Kraków, Poland Jagiellonian University Medical College, Pediatric Institute, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics; Children’s University Hospital, Kraków, Poland Jagiellonian University Medical College, Pediatric Institute, Department of Pediatric and Adolescent Endocrinology, Chair of Pediatrics; Children’s University Hospital, Kraków, Poland Objective:Elevated liver function tests (LFTs) are common in adult Turner syndrome (TS) patients. Data regarding children and adolescents are lacking. To investigate the prevalence of abnormal LFTs in children and adolescents with TS during several years of observation; to evaluate the potential impact of increased body mass index (BMI) and sex hormone replacement therapy (HRT) on LFTs.Methods:The analysis included 100 girls with TS, aged 4-16 years, all of whom were receiving recombinant human growth hormone therapy. A longitudinal study was conducted which included 81 patients.Results:Mean BMI-standard deviation (SD) score of the subjects was 0.63 (SD: 1.53). Forty-four were being treated with HRT. Elevated LFTs were found in 34% of the patients overall (32% not receiving HRT vs 36% on HRT). The relative risk of increased LFTs was not higher in obese vs normal weight [odds ratio (OR): 0.2; 95% confidence interval (CI): 0.1-0.36, p=0.38 vs OR: 0.16; 95% CI: 0.08-0.3, p=0.1]. HRT did not increase the risk of abnormal LFTs activity (OR: 0.8; 95% CI: 0.5-1.2, p=0.37 vs OR: 0.7; 95% CI: 0.4-1.1, p=0.27). During the follow-up period (mean±SD=4.31±0.82 years), no patient developed overt liver disease. There was no significant increase nor decrease of abnormal LFT frequency in the subsequent years of follow up.Conclusion:Constantly elevated LFTs in TS are common in children and adolescents with TS. However the causes and clinical significance remain unclear. This study suggests that obesity and HRT do not increase the risk of elevated LFTs. http://www.jcrpe.org/archives/archive-detail/article-preview/liver-biochemical-abnormalities-in-adolescent-pati/27600 turner syndromechildrenliverestrogen |
| spellingShingle | Małgorzata Wójcik Anna Ruszała Dominika Januś Jerzy B. Starzyk Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome JCRPE turner syndrome children liver estrogen |
| title | Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome |
| title_full | Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome |
| title_fullStr | Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome |
| title_full_unstemmed | Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome |
| title_short | Liver Biochemical Abnormalities in Adolescent Patients with Turner Syndrome |
| title_sort | liver biochemical abnormalities in adolescent patients with turner syndrome |
| topic | turner syndrome children liver estrogen |
| url |
http://www.jcrpe.org/archives/archive-detail/article-preview/liver-biochemical-abnormalities-in-adolescent-pati/27600
|
| work_keys_str_mv | AT małgorzatawojcik liverbiochemicalabnormalitiesinadolescentpatientswithturnersyndrome AT annaruszała liverbiochemicalabnormalitiesinadolescentpatientswithturnersyndrome AT dominikajanus liverbiochemicalabnormalitiesinadolescentpatientswithturnersyndrome AT jerzybstarzyk liverbiochemicalabnormalitiesinadolescentpatientswithturnersyndrome |