Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection
Background The relationship between aurora kinase A (Aurora A) expression level in the medullary thyroid carcinoma (MTC) tissue and the clinicopathological characteristics and biochemical cure of patients remains unclear. Objective To analyze the relationship between Aurora A expression level in med...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-07-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220883.pdf |
| _version_ | 1797216613441732608 |
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| author | ZHAO Zewei, KANG Ning, GUO Fengli, WANG Zhongyu, ZHENG Xiangqian |
| author_facet | ZHAO Zewei, KANG Ning, GUO Fengli, WANG Zhongyu, ZHENG Xiangqian |
| author_sort | ZHAO Zewei, KANG Ning, GUO Fengli, WANG Zhongyu, ZHENG Xiangqian |
| collection | DOAJ |
| description | Background The relationship between aurora kinase A (Aurora A) expression level in the medullary thyroid carcinoma (MTC) tissue and the clinicopathological characteristics and biochemical cure of patients remains unclear. Objective To analyze the relationship between Aurora A expression level in medullary thyroid tissue and the clinicopathological characteristics of patients, to further analyze the risk factors for biochemical cure and clarify the correlation between Aurora A expression and biochemical cure. Methods A total of 90 patients with MTC who were hospitalized with MTC resection in the Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital from February 2011 to July 2019 were enrolled, the clinical data of the patients were collected, and Aurora A expression level in the tissues was detected by immunohistochemical detection, and the influencing factors of biochemical cure of MTC patients were explored by multivariate Logistic regression model. Results 62 patients with high Aurora A expression level and 28 patients with low Aurora A expression were included, 40 patients achieved biochemical cure and 18 patients experienced recurrence. There were significant differences in gender, maximum tumor length, T stage, N stage, AJCC8th clinical stage, biochemical cure, and recurrence between patients with high Aurora A expression level and low Aurora A expression level (P<0.05). There were significant differences in gender, number of lesions, T stage, N stage, AJCC8th clinical stage, and Aurora A expression level between biochemically cured patients and those who were not biochemically cured (P<0.05). Multiple lesions〔OR=3.18, 95%CI (1.01, 9.97), P=0.047〕, T staging as T3/T4〔OR=3.69, 95%CI (1.05, 12.93), P=0.042〕, and high Aurora A expression level〔OR=3.22, 95%CI (1.07, 9.74), P=0.038〕were the influencing factors of biochemical cure in patients with MTC. Conclusion High Aurora A expression level is associated with tumor invasion of MTC, and the expression level of Aurora A can influence the biochemical cure in patients with MTC. |
| first_indexed | 2024-04-24T11:48:45Z |
| format | Article |
| id | doaj.art-1adb10348f8c43afa12bf1f9b62b7d15 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:48:45Z |
| publishDate | 2023-07-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-1adb10348f8c43afa12bf1f9b62b7d152024-04-09T08:12:48ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-07-0126202508251210.12114/j.issn.1007-9572.2022.0883Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer ResectionZHAO Zewei, KANG Ning, GUO Fengli, WANG Zhongyu, ZHENG Xiangqian0Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer/Tianjin's Clinical Research Center for Cancer//Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, ChinaBackground The relationship between aurora kinase A (Aurora A) expression level in the medullary thyroid carcinoma (MTC) tissue and the clinicopathological characteristics and biochemical cure of patients remains unclear. Objective To analyze the relationship between Aurora A expression level in medullary thyroid tissue and the clinicopathological characteristics of patients, to further analyze the risk factors for biochemical cure and clarify the correlation between Aurora A expression and biochemical cure. Methods A total of 90 patients with MTC who were hospitalized with MTC resection in the Department of Head and Neck Oncology, Tianjin Medical University Cancer Institute and Hospital from February 2011 to July 2019 were enrolled, the clinical data of the patients were collected, and Aurora A expression level in the tissues was detected by immunohistochemical detection, and the influencing factors of biochemical cure of MTC patients were explored by multivariate Logistic regression model. Results 62 patients with high Aurora A expression level and 28 patients with low Aurora A expression were included, 40 patients achieved biochemical cure and 18 patients experienced recurrence. There were significant differences in gender, maximum tumor length, T stage, N stage, AJCC8th clinical stage, biochemical cure, and recurrence between patients with high Aurora A expression level and low Aurora A expression level (P<0.05). There were significant differences in gender, number of lesions, T stage, N stage, AJCC8th clinical stage, and Aurora A expression level between biochemically cured patients and those who were not biochemically cured (P<0.05). Multiple lesions〔OR=3.18, 95%CI (1.01, 9.97), P=0.047〕, T staging as T3/T4〔OR=3.69, 95%CI (1.05, 12.93), P=0.042〕, and high Aurora A expression level〔OR=3.22, 95%CI (1.07, 9.74), P=0.038〕were the influencing factors of biochemical cure in patients with MTC. Conclusion High Aurora A expression level is associated with tumor invasion of MTC, and the expression level of Aurora A can influence the biochemical cure in patients with MTC.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220883.pdfthyroid tumors|carcinoma, medullary|aurora kinase a|prognosis|cohort studies|biochemical cure|root cause analysis |
| spellingShingle | ZHAO Zewei, KANG Ning, GUO Fengli, WANG Zhongyu, ZHENG Xiangqian Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection Zhongguo quanke yixue thyroid tumors|carcinoma, medullary|aurora kinase a|prognosis|cohort studies|biochemical cure|root cause analysis |
| title | Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection |
| title_full | Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection |
| title_fullStr | Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection |
| title_full_unstemmed | Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection |
| title_short | Effect of Aurora Kinase A Expression on Biochemical Cure in Patients after Medullary Thyroid Cancer Resection |
| title_sort | effect of aurora kinase a expression on biochemical cure in patients after medullary thyroid cancer resection |
| topic | thyroid tumors|carcinoma, medullary|aurora kinase a|prognosis|cohort studies|biochemical cure|root cause analysis |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220883.pdf |
| work_keys_str_mv | AT zhaozeweikangningguofengliwangzhongyuzhengxiangqian effectofaurorakinaseaexpressiononbiochemicalcureinpatientsaftermedullarythyroidcancerresection |