Antistreptolysin O titer in health and disease: levels and significance
Over diagnosis of acute rheumatic fever (ARF) based on a raised antistreptolysin O titer (ASOT) is not uncommon in endemic areas. In this study, 660 children (aged 9.2 ±1.7 years) were recruited consecutively and classified as: G1 (control group, n=200 healthy children), G2 (n=20 with ARF 1st attack...
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-02-01
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| Series: | Pediatric Reports |
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| Online Access: | http://www.pagepress.org/journals/index.php/pr/article/view/3553 |
| _version_ | 1818600849682726912 |
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| author | Alyaa Amal Kotby Nevin Mamdouh Habeeb Sahar Ezz El Arab |
| author_facet | Alyaa Amal Kotby Nevin Mamdouh Habeeb Sahar Ezz El Arab |
| author_sort | Alyaa Amal Kotby |
| collection | DOAJ |
| description | Over diagnosis of acute rheumatic fever (ARF) based on a raised antistreptolysin O titer (ASOT) is not uncommon in endemic areas. In this study, 660 children (aged 9.2 ±1.7 years) were recruited consecutively and classified as: G1 (control group, n=200 healthy children), G2 (n=20 with ARF 1st attack), G3 (n=40 with recurrent ARF), G4 (n=100 with rheumatic heart disease (RHD) on long acting penicillin (LAP)), G5 (n=100 with acute follicular tonsillitis), and G6 (n=200 healthy children with history of repeated follicular tonsillitis more than three times a year). Serum ASOT was measured by latex agglutination. Upper limit of normal (ULN) ASOT (80th percentile) was 400 IU in G1, 200 IU in G4, and 1600 IU in G6. Significantly high levels were seen in ARF 1st attack when compared to groups 1 and 5 (P<0.001 and P<0.05, respectively). ASOT was significantly high in children over ten years of age, during winter and in those with acute rheumatic carditis. ASOT showed significant direct correlation with the number of attacks of tonsillitis (P<0.05). Egyptian children have high ULN ASOT reaching 400 IU. This has to be taken into consideration when interpreting its values in suspected ARF. A rise in ASOT is less prominent in recurrent ARF compared to 1st attack, and acute and recurrent tonsillitis. Basal levels of ASOT increase with age but the pattern of increase during infection is not age dependent |
| first_indexed | 2024-12-16T12:42:02Z |
| format | Article |
| id | doaj.art-1adc1582a2904861875b517260f0c8e2 |
| institution | Directory Open Access Journal |
| issn | 2036-749X 2036-7503 |
| language | English |
| last_indexed | 2024-12-16T12:42:02Z |
| publishDate | 2012-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-1adc1582a2904861875b517260f0c8e22022-12-21T22:31:24ZengMDPI AGPediatric Reports2036-749X2036-75032012-02-0141e8e810.4081/pr.2012.e81976Antistreptolysin O titer in health and disease: levels and significanceAlyaa Amal Kotby0Nevin Mamdouh Habeeb1Sahar Ezz El Arab2Pediatric Department, Ain Shams University, CairoPediatric Department, Ain Shams University, CairoEarly Cancer Detection Unit, Ain Shams University Hospital, CairoOver diagnosis of acute rheumatic fever (ARF) based on a raised antistreptolysin O titer (ASOT) is not uncommon in endemic areas. In this study, 660 children (aged 9.2 ±1.7 years) were recruited consecutively and classified as: G1 (control group, n=200 healthy children), G2 (n=20 with ARF 1st attack), G3 (n=40 with recurrent ARF), G4 (n=100 with rheumatic heart disease (RHD) on long acting penicillin (LAP)), G5 (n=100 with acute follicular tonsillitis), and G6 (n=200 healthy children with history of repeated follicular tonsillitis more than three times a year). Serum ASOT was measured by latex agglutination. Upper limit of normal (ULN) ASOT (80th percentile) was 400 IU in G1, 200 IU in G4, and 1600 IU in G6. Significantly high levels were seen in ARF 1st attack when compared to groups 1 and 5 (P<0.001 and P<0.05, respectively). ASOT was significantly high in children over ten years of age, during winter and in those with acute rheumatic carditis. ASOT showed significant direct correlation with the number of attacks of tonsillitis (P<0.05). Egyptian children have high ULN ASOT reaching 400 IU. This has to be taken into consideration when interpreting its values in suspected ARF. A rise in ASOT is less prominent in recurrent ARF compared to 1st attack, and acute and recurrent tonsillitis. Basal levels of ASOT increase with age but the pattern of increase during infection is not age dependenthttp://www.pagepress.org/journals/index.php/pr/article/view/3553antistreptolysin O titer, rheumatic fever |
| spellingShingle | Alyaa Amal Kotby Nevin Mamdouh Habeeb Sahar Ezz El Arab Antistreptolysin O titer in health and disease: levels and significance Pediatric Reports antistreptolysin O titer, rheumatic fever |
| title | Antistreptolysin O titer in health and disease: levels and significance |
| title_full | Antistreptolysin O titer in health and disease: levels and significance |
| title_fullStr | Antistreptolysin O titer in health and disease: levels and significance |
| title_full_unstemmed | Antistreptolysin O titer in health and disease: levels and significance |
| title_short | Antistreptolysin O titer in health and disease: levels and significance |
| title_sort | antistreptolysin o titer in health and disease levels and significance |
| topic | antistreptolysin O titer, rheumatic fever |
| url | http://www.pagepress.org/journals/index.php/pr/article/view/3553 |
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