Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review
Skin conditions are a significant cause of fatal and nonfatal disease burdens globally, ranging from mild irritations to debilitating diseases. Oxidative stress, which is an imbalance between reactive oxygen species and the cells’ ability to repair damage, is implicated in various skin diseases. Ant...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/8/1503 |
| _version_ | 1797585660426584064 |
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| author | Jasmine Thuy Tran Michael Joseph Diaz Daphnee Rodriguez Giona Kleinberg Shaliz Aflatooni Siri Palreddy Parsa Abdi Kamil Taneja Sai Batchu Mahtab Forouzandeh |
| author_facet | Jasmine Thuy Tran Michael Joseph Diaz Daphnee Rodriguez Giona Kleinberg Shaliz Aflatooni Siri Palreddy Parsa Abdi Kamil Taneja Sai Batchu Mahtab Forouzandeh |
| author_sort | Jasmine Thuy Tran |
| collection | DOAJ |
| description | Skin conditions are a significant cause of fatal and nonfatal disease burdens globally, ranging from mild irritations to debilitating diseases. Oxidative stress, which is an imbalance between reactive oxygen species and the cells’ ability to repair damage, is implicated in various skin diseases. Antioxidants have been studied for their potential benefits in dermatologic health, but the evidence is limited and conflicting. Herein, we conducted a systematic review of controlled trials, meta-analyses, and Cochrane review articles to evaluate the current evidence on the utility of antioxidant supplementation for adjunct prevention and treatment of skin disease and to provide a comprehensive assessment of their role in promoting dermatologic health. The Cochrane Library, PubMed, EMBASE, and Epistemonikos databases were queried. Eligibility criteria included (1) primary focus on nanoparticle utility for skin cancer; (2) includes measurable outcomes data with robust comparators; (3) includes a number of human subjects or cell-line types, where applicable; (4) English language; and (5) archived as full-text journal articles. A total of 55 articles met the eligibility criteria for the present review. Qualitative analysis revealed that topical and oral antioxidant supplementation has demonstrated preliminary efficacy in reducing sunburns, depigmentation, and photoaging. Dietary exogenous antioxidants (namely vitamins A, C, and E) have shown chemopreventive effects against skin cancer. Antioxidant supplementation has also shown efficacy in treating non-cancer dermatoses, including rosacea, psoriasis, atopic dermatitis, and acne vulgaris. While further studies are needed to validate these findings on a larger scale, antioxidant supplementation holds promise for improving skin health and preventing skin diseases. |
| first_indexed | 2024-03-11T00:10:14Z |
| format | Article |
| id | doaj.art-1adc5c2c0101429c98554bdd08e9d870 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:14Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-1adc5c2c0101429c98554bdd08e9d8702023-11-19T00:00:48ZengMDPI AGAntioxidants2076-39212023-07-01128150310.3390/antiox12081503Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic ReviewJasmine Thuy Tran0Michael Joseph Diaz1Daphnee Rodriguez2Giona Kleinberg3Shaliz Aflatooni4Siri Palreddy5Parsa Abdi6Kamil Taneja7Sai Batchu8Mahtab Forouzandeh9School of Medicine, Indiana University, Indianapolis, IN 46202, USACollege of Medicine, University of Florida, Gainesville, FL 32610, USACollege of Medicine, University of Central Florida, Orlando, FL 32827, USACollege of Engineering, Northeastern University, Boston, MA 02115, USAMorsani College of Medicine, University of South Florida, Tampa, FL 33602, USADepartment of Biology, Amherst College, Amherst, MA 01002, USAFaculty of Medicine, Memorial University, St. Johns, NL A1B 3V6, CanadaRenaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USACooper Medical School, Rowan University, Camden, NJ 08103, USADepartment of Dermatology, University of Florida, Gainesville, FL 32606, USASkin conditions are a significant cause of fatal and nonfatal disease burdens globally, ranging from mild irritations to debilitating diseases. Oxidative stress, which is an imbalance between reactive oxygen species and the cells’ ability to repair damage, is implicated in various skin diseases. Antioxidants have been studied for their potential benefits in dermatologic health, but the evidence is limited and conflicting. Herein, we conducted a systematic review of controlled trials, meta-analyses, and Cochrane review articles to evaluate the current evidence on the utility of antioxidant supplementation for adjunct prevention and treatment of skin disease and to provide a comprehensive assessment of their role in promoting dermatologic health. The Cochrane Library, PubMed, EMBASE, and Epistemonikos databases were queried. Eligibility criteria included (1) primary focus on nanoparticle utility for skin cancer; (2) includes measurable outcomes data with robust comparators; (3) includes a number of human subjects or cell-line types, where applicable; (4) English language; and (5) archived as full-text journal articles. A total of 55 articles met the eligibility criteria for the present review. Qualitative analysis revealed that topical and oral antioxidant supplementation has demonstrated preliminary efficacy in reducing sunburns, depigmentation, and photoaging. Dietary exogenous antioxidants (namely vitamins A, C, and E) have shown chemopreventive effects against skin cancer. Antioxidant supplementation has also shown efficacy in treating non-cancer dermatoses, including rosacea, psoriasis, atopic dermatitis, and acne vulgaris. While further studies are needed to validate these findings on a larger scale, antioxidant supplementation holds promise for improving skin health and preventing skin diseases.https://www.mdpi.com/2076-3921/12/8/1503antioxidant supplementationvitaminsreactive oxygen speciesskin cancerdermatology |
| spellingShingle | Jasmine Thuy Tran Michael Joseph Diaz Daphnee Rodriguez Giona Kleinberg Shaliz Aflatooni Siri Palreddy Parsa Abdi Kamil Taneja Sai Batchu Mahtab Forouzandeh Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review Antioxidants antioxidant supplementation vitamins reactive oxygen species skin cancer dermatology |
| title | Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review |
| title_full | Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review |
| title_fullStr | Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review |
| title_full_unstemmed | Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review |
| title_short | Evidence-Based Utility of Adjunct Antioxidant Supplementation for the Prevention and Treatment of Dermatologic Diseases: A Comprehensive Systematic Review |
| title_sort | evidence based utility of adjunct antioxidant supplementation for the prevention and treatment of dermatologic diseases a comprehensive systematic review |
| topic | antioxidant supplementation vitamins reactive oxygen species skin cancer dermatology |
| url | https://www.mdpi.com/2076-3921/12/8/1503 |
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