Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees
Oxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486137/?tool=EBI |
| _version_ | 1828850520482119680 |
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| author | Nicole Thompson González Emily Otali Zarin Machanda Martin N. Muller Richard Wrangham Melissa Emery Thompson Emmanuel Serrano |
| author_facet | Nicole Thompson González Emily Otali Zarin Machanda Martin N. Muller Richard Wrangham Melissa Emery Thompson Emmanuel Serrano |
| author_sort | Nicole Thompson González |
| collection | DOAJ |
| description | Oxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions, particularly in primates, and their utility to non-invasively monitor the costs of acute stressors versus the long-term damage associated with aging is poorly understood. In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. We used 924 urine samples to examine responses to acute immune challenge (respiratory illness or severe wounding), as well as mixed-longitudinal and intra-individual variation with age. DNA damage (8-OHdG) correlated positively with all other markers of damage (F-isoprostanes, MDA-TBARS, and neopterin) but did not correlate with protection (total antioxidant capacity). Within individuals, all markers of damage responded to at least one if not both types of acute infection. While OS is expected to increase with age, this was not generally true in chimpanzees. However, significant changes in oxidative damage were detected within past-prime individuals and those close to death. Our results indicate that OS can be measured using field-collected urine and integrates short- and long-term aspects of health. They further suggest that more data are needed from long-lived, wild animals to illuminate if common age-related increases in inflammation and OS damage are typical or recently aberrant in humans. |
| first_indexed | 2024-12-12T23:13:32Z |
| format | Article |
| id | doaj.art-1adce0feb40e4bf5856387571d3a5c14 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T23:13:32Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1adce0feb40e4bf5856387571d3a5c142022-12-22T00:08:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01159Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzeesNicole Thompson GonzálezEmily OtaliZarin MachandaMartin N. MullerRichard WranghamMelissa Emery ThompsonEmmanuel SerranoOxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions, particularly in primates, and their utility to non-invasively monitor the costs of acute stressors versus the long-term damage associated with aging is poorly understood. In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. We used 924 urine samples to examine responses to acute immune challenge (respiratory illness or severe wounding), as well as mixed-longitudinal and intra-individual variation with age. DNA damage (8-OHdG) correlated positively with all other markers of damage (F-isoprostanes, MDA-TBARS, and neopterin) but did not correlate with protection (total antioxidant capacity). Within individuals, all markers of damage responded to at least one if not both types of acute infection. While OS is expected to increase with age, this was not generally true in chimpanzees. However, significant changes in oxidative damage were detected within past-prime individuals and those close to death. Our results indicate that OS can be measured using field-collected urine and integrates short- and long-term aspects of health. They further suggest that more data are needed from long-lived, wild animals to illuminate if common age-related increases in inflammation and OS damage are typical or recently aberrant in humans.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486137/?tool=EBI |
| spellingShingle | Nicole Thompson González Emily Otali Zarin Machanda Martin N. Muller Richard Wrangham Melissa Emery Thompson Emmanuel Serrano Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees PLoS ONE |
| title | Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees |
| title_full | Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees |
| title_fullStr | Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees |
| title_full_unstemmed | Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees |
| title_short | Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees |
| title_sort | urinary markers of oxidative stress respond to infection and late life in wild chimpanzees |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486137/?tool=EBI |
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