Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities
The growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive ligands and metals that are already consolidated in th...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/8/331 |
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| author | Amanda A. Silva Silmara C. L. Frajácomo Állefe B. Cruz Kaio Eduardo Buglio Daniele Daiane Affonso Marcelo Cecconi Portes Ana Lúcia T. G. Ruiz João Ernesto de Carvalho Wilton R. Lustri Douglas H. Pereira Ana M. da Costa Ferreira Pedro P. Corbi |
| author_facet | Amanda A. Silva Silmara C. L. Frajácomo Állefe B. Cruz Kaio Eduardo Buglio Daniele Daiane Affonso Marcelo Cecconi Portes Ana Lúcia T. G. Ruiz João Ernesto de Carvalho Wilton R. Lustri Douglas H. Pereira Ana M. da Costa Ferreira Pedro P. Corbi |
| author_sort | Amanda A. Silva |
| collection | DOAJ |
| description | The growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive ligands and metals that are already consolidated in the synthesis of metallopharmaceutical agents. Thus, this work deals with the synthesis, characterization, and study of naproxen (Nap)-based complexes of copper(II) and platinum(II) as antiproliferative agents. The copper complex (Cu–Nap) presents a binuclear paddle-wheel structure in a 1 Cu:2 Nap:1 H<sub>2</sub>O molar composition, in which Cu(II) is bonded to the carboxylate oxygens from naproxenate in a bidentate bridging mode. The platinum complex (Pt–Nap) was identified as the square planar <i>cis</i>-[Pt(Nap)<sub>2</sub>(DMSO)<sub>2</sub>] isomer, in which Pt(II) is bonded to the carboxylate oxygen atom of Nap in a monodentate fashion. Both complexes were inactive against the Gram-positive and Gram-negative bacterial strains assessed. Pt–Nap presented low cytostatic behavior over a set of tumor cells, but good viability for normal cells, while Cu–Nap was cytotoxic against all cells, with a cytocidal activity against glioma tumor cells. |
| first_indexed | 2024-03-10T23:51:08Z |
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| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-10T23:51:08Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-1adce2202e1344e8bedea21371e73b5c2023-11-19T01:35:42ZengMDPI AGInorganics2304-67402023-08-0111833110.3390/inorganics11080331Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative ActivitiesAmanda A. Silva0Silmara C. L. Frajácomo1Állefe B. Cruz2Kaio Eduardo Buglio3Daniele Daiane Affonso4Marcelo Cecconi Portes5Ana Lúcia T. G. Ruiz6João Ernesto de Carvalho7Wilton R. Lustri8Douglas H. Pereira9Ana M. da Costa Ferreira10Pedro P. Corbi11Institute of Chemistry, University of Campinas—UNICAMP, Campinas 13083-970, SP, BrazilDepartment of Biological and Health Sciences, University of Araraquara—UNIARA, Araraquara 14801-320, SP, BrazilChemistry Collegiate, Federal University of Tocantins—UFT, Gurupi 77402-970, TO, BrazilFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, BrazilFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, BrazilDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo—USP, São Paulo 05508-000, SP, BrazilFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, BrazilFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, BrazilDepartment of Biological and Health Sciences, University of Araraquara—UNIARA, Araraquara 14801-320, SP, BrazilChemistry Collegiate, Federal University of Tocantins—UFT, Gurupi 77402-970, TO, BrazilDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo—USP, São Paulo 05508-000, SP, BrazilInstitute of Chemistry, University of Campinas—UNICAMP, Campinas 13083-970, SP, BrazilThe growth of antibiotic resistance is a matter of worldwide concern. In parallel, cancer remains one of the main causes of death. In the search for new and improved antiproliferative agents, one of the strategies is the combination of bioactive ligands and metals that are already consolidated in the synthesis of metallopharmaceutical agents. Thus, this work deals with the synthesis, characterization, and study of naproxen (Nap)-based complexes of copper(II) and platinum(II) as antiproliferative agents. The copper complex (Cu–Nap) presents a binuclear paddle-wheel structure in a 1 Cu:2 Nap:1 H<sub>2</sub>O molar composition, in which Cu(II) is bonded to the carboxylate oxygens from naproxenate in a bidentate bridging mode. The platinum complex (Pt–Nap) was identified as the square planar <i>cis</i>-[Pt(Nap)<sub>2</sub>(DMSO)<sub>2</sub>] isomer, in which Pt(II) is bonded to the carboxylate oxygen atom of Nap in a monodentate fashion. Both complexes were inactive against the Gram-positive and Gram-negative bacterial strains assessed. Pt–Nap presented low cytostatic behavior over a set of tumor cells, but good viability for normal cells, while Cu–Nap was cytotoxic against all cells, with a cytocidal activity against glioma tumor cells.https://www.mdpi.com/2304-6740/11/8/331NSAIDscopper(II)platinum(II)naproxenantibacterial agentsantiproliferative activities |
| spellingShingle | Amanda A. Silva Silmara C. L. Frajácomo Állefe B. Cruz Kaio Eduardo Buglio Daniele Daiane Affonso Marcelo Cecconi Portes Ana Lúcia T. G. Ruiz João Ernesto de Carvalho Wilton R. Lustri Douglas H. Pereira Ana M. da Costa Ferreira Pedro P. Corbi Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities Inorganics NSAIDs copper(II) platinum(II) naproxen antibacterial agents antiproliferative activities |
| title | Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities |
| title_full | Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities |
| title_fullStr | Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities |
| title_full_unstemmed | Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities |
| title_short | Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities |
| title_sort | copper ii and platinum ii naproxenates insights on synthesis characterization and evaluation of their antiproliferative activities |
| topic | NSAIDs copper(II) platinum(II) naproxen antibacterial agents antiproliferative activities |
| url | https://www.mdpi.com/2304-6740/11/8/331 |
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