Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2021-04-01
Schriftenreihe:Brain Sciences
Schlagworte:
upper motor neurons
protein landscape
interaction domain
upstream regulator
lipid homeostasis
growth factors
Online Zugang:https://www.mdpi.com/2076-3425/11/5/578

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https://www.mdpi.com/2076-3425/11/5/578

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