Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

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Detalles Bibliográficos
Main Authors: Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Formato: Artigo
Idioma:English
Publicado: MDPI AG 2021-04-01
Series:Brain Sciences
Subjects:
upper motor neurons
protein landscape
interaction domain
upstream regulator
lipid homeostasis
growth factors
Acceso en liña:https://www.mdpi.com/2076-3425/11/5/578

Internet

https://www.mdpi.com/2076-3425/11/5/578

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