Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

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Autori principali: Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Natura: Articolo
Lingua:English
Pubblicazione: MDPI AG 2021-04-01
Serie:Brain Sciences
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Accesso online:https://www.mdpi.com/2076-3425/11/5/578