Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

詳細記述

書誌詳細
主要な著者: Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
フォーマット: 論文
言語:English
出版事項: MDPI AG 2021-04-01
シリーズ:Brain Sciences
主題:
オンライン・アクセス:https://www.mdpi.com/2076-3425/11/5/578