Mutations and Protein Interaction Landscape Reveal Key Cellular Events Perturbed in Upper Motor Neurons with HSP and PLS

Hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS) are rare motor neuron diseases, which affect mostly the upper motor neurons (UMNs) in patients. The UMNs display early vulnerability and progressive degeneration, while other cortical neurons mostly remain functional. Identifica...

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Bibliografische gegevens
Hoofdauteurs: Oge Gozutok, Benjamin Ryan Helmold, P. Hande Ozdinler
Formaat: Artikel
Taal:English
Gepubliceerd in: MDPI AG 2021-04-01
Reeks:Brain Sciences
Onderwerpen:
Online toegang:https://www.mdpi.com/2076-3425/11/5/578