Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis

Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis

The newly established CD3FLAG-mIR transgenic mouse model on a C57Bl/6 background has a FLAG tag on the mouse Insulin Receptor (mIR), specifically on T cells, as the FLAG-tagged mIR gene was engineered behind CD3 promoter and enhancer. The IR is a chemotactic molecule for insulin and the Flag-tagged...

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Bibliographic Details
Main Authors:	Emily Esakov, Neha Nandedkar-Kulkarni, Ali G. Al-Dieri, Hannah Hafner, Brigid Gregg, Marcia F. McInerney
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Biomolecules
Subjects:	pancreatic islets insulitis T cell insulin receptor glucose metabolism
Online Access:	https://www.mdpi.com/2218-273X/11/4/552

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