A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit

A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit

We describe a regulatory mechanism that controls the activity of retromer, an evolutionarily conserved sorting device that orchestrates cargo export from the endosome. A spontaneously arising mutation that activates the yeast (Saccharomyces cerevisiae) CDC25 family phosphatase, Mih1, results in acce...

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Bibliographic Details
Main Authors: Tie-Zhong Cui, Tabitha A Peterson, Christopher G Burd
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-03-01
Series:eLife
Subjects:
retromer
endosome
CDC25 protein phosphatase
arrestin
Online Access:https://elifesciences.org/articles/24126

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