SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Abstract Background The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttranslational modification (PTM) which regulates protein stability, locali...

Full description

Bibliographic Details
Main Authors: Kehuan Wang, Natalia Papadopoulos, Anahita Hamidi, Johan Lennartsson, Carl-Henrik Heldin
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Molecular and Cell Biology
Subjects:
PDGFRα
Receptor tyrosine kinase
SUMO
SUMOylation
Online Access:https://doi.org/10.1186/s12860-023-00481-6

Similar Items

Similar Items