Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity
According to the neuroprotective effects of Zn metal and Elaeagnus angustifolia leaves separately, we tried to synthesize a modern neuroprotective drug (ZnNPs in an aqueous medium by E. angustifolia leaves extract). After ZnNPs synthesizing, they were analyzed by UV-Vis. and FT-IR spectroscopy and F...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
|
| Series: | Journal of Experimental Nanoscience |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/17458080.2022.2120193 |
| _version_ | 1811261848580784128 |
|---|---|
| author | Mingzong Yan Junmei Li |
| author_facet | Mingzong Yan Junmei Li |
| author_sort | Mingzong Yan |
| collection | DOAJ |
| description | According to the neuroprotective effects of Zn metal and Elaeagnus angustifolia leaves separately, we tried to synthesize a modern neuroprotective drug (ZnNPs in an aqueous medium by E. angustifolia leaves extract). After ZnNPs synthesizing, they were analyzed by UV-Vis. and FT-IR spectroscopy and FE-SEM. The sizes of 10–50 nm were seen by FE-SEM images in our nanoparticles. In addition, the nanoparticles were spherical morphologically. To investigate the antioxidant effects, DPPH free radicals test was used. The ZnNPs removed half of the free radicals at the 27 µg/mL concentration. In the neurological experiments, we concluded that Nicotine causes cell death in nerve-like PC12 cells by inducing apoptosis and cell inflammation. Zinc nanoparticles repressed the inflammatory cytokines (IL-1β, IL-6, and TNF-α) production, caspase 3 activity, and mitochondrial membrane disruption. These events showed that zinc nanoparticles repressed Nicotine-induced cell death in PC12 cells, in a dose-dependent manner. |
| first_indexed | 2024-04-12T19:13:13Z |
| format | Article |
| id | doaj.art-1ae23d464e3f4804b98702b879566029 |
| institution | Directory Open Access Journal |
| issn | 1745-8080 1745-8099 |
| language | English |
| last_indexed | 2024-04-12T19:13:13Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Experimental Nanoscience |
| spelling | doaj.art-1ae23d464e3f4804b98702b8795660292022-12-22T03:19:49ZengTaylor & Francis GroupJournal of Experimental Nanoscience1745-80801745-80992022-12-0117154856310.1080/17458080.2022.2120193Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicityMingzong Yan0Junmei Li1Department of Brain Diseases, Penglai City Hospital of Traditional Chinese Medicine, Yantai, Shandong, ChinaDepartment of Internal Medicine, Penglai Traditional Chinese Medicine Hospital, Yantai, Shandong, ChinaAccording to the neuroprotective effects of Zn metal and Elaeagnus angustifolia leaves separately, we tried to synthesize a modern neuroprotective drug (ZnNPs in an aqueous medium by E. angustifolia leaves extract). After ZnNPs synthesizing, they were analyzed by UV-Vis. and FT-IR spectroscopy and FE-SEM. The sizes of 10–50 nm were seen by FE-SEM images in our nanoparticles. In addition, the nanoparticles were spherical morphologically. To investigate the antioxidant effects, DPPH free radicals test was used. The ZnNPs removed half of the free radicals at the 27 µg/mL concentration. In the neurological experiments, we concluded that Nicotine causes cell death in nerve-like PC12 cells by inducing apoptosis and cell inflammation. Zinc nanoparticles repressed the inflammatory cytokines (IL-1β, IL-6, and TNF-α) production, caspase 3 activity, and mitochondrial membrane disruption. These events showed that zinc nanoparticles repressed Nicotine-induced cell death in PC12 cells, in a dose-dependent manner.https://www.tandfonline.com/doi/10.1080/17458080.2022.2120193ZnNPsElaeagnus angustifolia leavesneuroprotectiveantioxidantnicotine |
| spellingShingle | Mingzong Yan Junmei Li Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity Journal of Experimental Nanoscience ZnNPs Elaeagnus angustifolia leaves neuroprotective antioxidant nicotine |
| title | Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity |
| title_full | Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity |
| title_fullStr | Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity |
| title_full_unstemmed | Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity |
| title_short | Elaeagnus angustifolia extract green-formulated zinc nanoparticles possess a protective activity against nicotine-induced neurotoxicity |
| title_sort | elaeagnus angustifolia extract green formulated zinc nanoparticles possess a protective activity against nicotine induced neurotoxicity |
| topic | ZnNPs Elaeagnus angustifolia leaves neuroprotective antioxidant nicotine |
| url | https://www.tandfonline.com/doi/10.1080/17458080.2022.2120193 |
| work_keys_str_mv | AT mingzongyan elaeagnusangustifoliaextractgreenformulatedzincnanoparticlespossessaprotectiveactivityagainstnicotineinducedneurotoxicity AT junmeili elaeagnusangustifoliaextractgreenformulatedzincnanoparticlespossessaprotectiveactivityagainstnicotineinducedneurotoxicity |