Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis
Delayed graft function (DGF) is a frequent complication of kidney transplantation, but its impact on long- and short-term transplant outcomes is unclear. We conducted a systematic literature search for studies published from 2007 to 2020 investigating the association between DGF and posttransplant o...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2023-02-01
|
| Series: | Transplantation Direct |
| Online Access: | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001433 |
| _version_ | 1797894105469026304 |
|---|---|
| author | Miah T. Li, MS Adarsh Ramakrishnan, MPH Miko Yu, MA Emily Daniel, MD Vanessa Sandra, MPH Navin Sanichar, MPH Kristen L. King, MPH Jacob S. Stevens, MD S. Ali Husain, MD, MPH Sumit Mohan, MD, MPH |
| author_facet | Miah T. Li, MS Adarsh Ramakrishnan, MPH Miko Yu, MA Emily Daniel, MD Vanessa Sandra, MPH Navin Sanichar, MPH Kristen L. King, MPH Jacob S. Stevens, MD S. Ali Husain, MD, MPH Sumit Mohan, MD, MPH |
| author_sort | Miah T. Li, MS |
| collection | DOAJ |
| description | Delayed graft function (DGF) is a frequent complication of kidney transplantation, but its impact on long- and short-term transplant outcomes is unclear. We conducted a systematic literature search for studies published from 2007 to 2020 investigating the association between DGF and posttransplant outcomes. Forest plots stratified between center studies and registry studies were created with pooled odds ratios. Posttransplant outcomes including graft failure, acute rejection, patient mortality, and kidney function were analyzed. Of the 3422 articles reviewed, 38 papers were included in this meta-analysis. In single-center studies, patients who experienced DGF had increased graft failure (odds ratio [OR] 3.38; 95% confidence interval [CI], 1.85-6.17; P < 0.01), acute allograft rejection (OR 1.84; 95% CI, 1.30-2.61; P < 0.01), and mortality (OR 2.32; 95% CI, 1.53-3.50; P < 0.01) at 1-y posttransplant. Registry studies showed increased graft failure (OR 3.66; 95% CI, 3.04-4.40; P < 0.01) and acute rejection (OR 3.24; 95% CI, 1.88-5.59; P < 0.01) but not mortality (OR 2.27; 95% CI, 0.97-5.34; P = 0.06) at 1-y posttransplant. DGF was associated with increased odds of graft failure, acute rejection, and mortality. These results in this meta-analysis could help inform the selection process, treatment, and monitoring of transplanted kidneys at high risk of DGF. |
| first_indexed | 2024-04-10T07:04:37Z |
| format | Article |
| id | doaj.art-1ae2b0bc3c804e3bbe73b546e0efbd20 |
| institution | Directory Open Access Journal |
| issn | 2373-8731 |
| language | English |
| last_indexed | 2024-04-10T07:04:37Z |
| publishDate | 2023-02-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Transplantation Direct |
| spelling | doaj.art-1ae2b0bc3c804e3bbe73b546e0efbd202023-02-27T09:04:07ZengWolters KluwerTransplantation Direct2373-87312023-02-0192e143310.1097/TXD.0000000000001433202302000-00006Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysisMiah T. Li, MS0Adarsh Ramakrishnan, MPH1Miko Yu, MA2Emily Daniel, MD3Vanessa Sandra, MPH4Navin Sanichar, MPH5Kristen L. King, MPH6Jacob S. Stevens, MD7S. Ali Husain, MD, MPH8Sumit Mohan, MD, MPH91 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.2 The Columbia University Renal Epidemiology (CURE) Group, Columbia University, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.3 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.3 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.1 Division of Nephrology, Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons, New York, NY.Delayed graft function (DGF) is a frequent complication of kidney transplantation, but its impact on long- and short-term transplant outcomes is unclear. We conducted a systematic literature search for studies published from 2007 to 2020 investigating the association between DGF and posttransplant outcomes. Forest plots stratified between center studies and registry studies were created with pooled odds ratios. Posttransplant outcomes including graft failure, acute rejection, patient mortality, and kidney function were analyzed. Of the 3422 articles reviewed, 38 papers were included in this meta-analysis. In single-center studies, patients who experienced DGF had increased graft failure (odds ratio [OR] 3.38; 95% confidence interval [CI], 1.85-6.17; P < 0.01), acute allograft rejection (OR 1.84; 95% CI, 1.30-2.61; P < 0.01), and mortality (OR 2.32; 95% CI, 1.53-3.50; P < 0.01) at 1-y posttransplant. Registry studies showed increased graft failure (OR 3.66; 95% CI, 3.04-4.40; P < 0.01) and acute rejection (OR 3.24; 95% CI, 1.88-5.59; P < 0.01) but not mortality (OR 2.27; 95% CI, 0.97-5.34; P = 0.06) at 1-y posttransplant. DGF was associated with increased odds of graft failure, acute rejection, and mortality. These results in this meta-analysis could help inform the selection process, treatment, and monitoring of transplanted kidneys at high risk of DGF.http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001433 |
| spellingShingle | Miah T. Li, MS Adarsh Ramakrishnan, MPH Miko Yu, MA Emily Daniel, MD Vanessa Sandra, MPH Navin Sanichar, MPH Kristen L. King, MPH Jacob S. Stevens, MD S. Ali Husain, MD, MPH Sumit Mohan, MD, MPH Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis Transplantation Direct |
| title | Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis |
| title_full | Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis |
| title_fullStr | Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis |
| title_full_unstemmed | Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis |
| title_short | Effects of Delayed Graft Function on Transplant Outcomes: A Meta-analysis |
| title_sort | effects of delayed graft function on transplant outcomes a meta analysis |
| url | http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001433 |
| work_keys_str_mv | AT miahtlims effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT adarshramakrishnanmph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT mikoyuma effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT emilydanielmd effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT vanessasandramph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT navinsanicharmph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT kristenlkingmph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT jacobsstevensmd effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT salihusainmdmph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis AT sumitmohanmdmph effectsofdelayedgraftfunctionontransplantoutcomesametaanalysis |