Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide
A series of three new hydrazone compounds derived from the condensation reactions of 4-dimethylaminobenzohydrazide with 4-dimethylaminobenzaldehyde, 2-chloro-5-nitrobenzaldehyde and 3-methoxybenzaldehyde, respectively, were prepared. The compounds were characterized by elemental analysis, infrared a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2021-09-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/6333 |
| _version_ | 1818888066318729216 |
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| author | Guo-Xu He Ling-Wei Xue |
| author_facet | Guo-Xu He Ling-Wei Xue |
| author_sort | Guo-Xu He |
| collection | DOAJ |
| description | A series of three new hydrazone compounds derived from the condensation reactions of 4-dimethylaminobenzohydrazide with 4-dimethylaminobenzaldehyde, 2-chloro-5-nitrobenzaldehyde and 3-methoxybenzaldehyde, respectively, were prepared. The compounds were characterized by elemental analysis, infrared and UV-vis spectra, HRMS, 1H NMR and 13C NMR spectra, and single crystal X-ray diffraction. Crystals of the compounds are stabilized by hydrogen bonds. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method. The results indicated that compound 2 is an effective antibacterial material. |
| first_indexed | 2024-12-19T16:47:13Z |
| format | Article |
| id | doaj.art-1ae3a582aff441e2b3628364d5c82000 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-12-19T16:47:13Z |
| publishDate | 2021-09-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-1ae3a582aff441e2b3628364d5c820002022-12-21T20:13:38ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552021-09-0168356757410.17344/acsi.2020.63331001Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-DimethylaminobenzohydrazideGuo-Xu He0Ling-Wei Xue1Pingdingshan UniversityPingdingshan UniversityA series of three new hydrazone compounds derived from the condensation reactions of 4-dimethylaminobenzohydrazide with 4-dimethylaminobenzaldehyde, 2-chloro-5-nitrobenzaldehyde and 3-methoxybenzaldehyde, respectively, were prepared. The compounds were characterized by elemental analysis, infrared and UV-vis spectra, HRMS, 1H NMR and 13C NMR spectra, and single crystal X-ray diffraction. Crystals of the compounds are stabilized by hydrogen bonds. The compounds were assayed for antibacterial (Bacillus subtilis, Escherichia coli, Pseudomonas fluorescence and Staphylococcus aureus) and antifungal (Aspergillus niger and Candida albicans) activities by MTT method. The results indicated that compound 2 is an effective antibacterial material.https://journals.matheo.si/index.php/ACSi/article/view/6333hydrazone compoundcrystal structurehydrogen bondsx-ray crystallographyantimicrobial activity |
| spellingShingle | Guo-Xu He Ling-Wei Xue Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide Acta Chimica Slovenica hydrazone compound crystal structure hydrogen bonds x-ray crystallography antimicrobial activity |
| title | Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide |
| title_full | Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide |
| title_fullStr | Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide |
| title_full_unstemmed | Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide |
| title_short | Synthesis, Structures, and Antibacterial Activities of Hydrazone Compounds Derived from 4-Dimethylaminobenzohydrazide |
| title_sort | synthesis structures and antibacterial activities of hydrazone compounds derived from 4 dimethylaminobenzohydrazide |
| topic | hydrazone compound crystal structure hydrogen bonds x-ray crystallography antimicrobial activity |
| url | https://journals.matheo.si/index.php/ACSi/article/view/6333 |
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