The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues
Abstract Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additional...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-02-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202306128 |
| _version_ | 1827197111646552064 |
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| author | Wenran Ren Meng Hua Fang Cao Wenwen Zeng |
| author_facet | Wenran Ren Meng Hua Fang Cao Wenwen Zeng |
| author_sort | Wenran Ren |
| collection | DOAJ |
| description | Abstract Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases. |
| first_indexed | 2024-03-07T22:48:14Z |
| format | Article |
| id | doaj.art-1ae8d4370a05499c8e262cd98c613ac6 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2025-03-21T09:55:56Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-1ae8d4370a05499c8e262cd98c613ac62024-07-05T09:51:16ZengWileyAdvanced Science2198-38442024-02-01118n/an/a10.1002/advs.202306128The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose TissuesWenran Ren0Meng Hua1Fang Cao2Wenwen Zeng3Institute for Immunology and School of Medicine Tsinghua University and Tsinghua‐Peking Center for Life Sciences Beijing 100084 ChinaInstitute for Immunology and School of Medicine Tsinghua University and Tsinghua‐Peking Center for Life Sciences Beijing 100084 ChinaDepartment of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 ChinaInstitute for Immunology and School of Medicine Tsinghua University and Tsinghua‐Peking Center for Life Sciences Beijing 100084 ChinaAbstract Sympathetic innervation plays a crucial role in maintaining energy balance and contributes to metabolic pathophysiology. Recent evidence has begun to uncover the innervation landscape of sympathetic projections and sheds light on their important functions in metabolic activities. Additionally, the immune system has long been studied for its essential roles in metabolic health and diseases. In this review, the aim is to provide an overview of the current research progress on the sympathetic regulation of key metabolic organs, including the pancreas, liver, intestine, and adipose tissues. In particular, efforts are made to highlight the critical roles of the peripheral nervous system and its potential interplay with immune components. Overall, it is hoped to underscore the importance of studying metabolic organs from a comprehensive and interconnected perspective, which will provide valuable insights into the complex mechanisms underlying metabolic regulation and may lead to novel therapeutic strategies for metabolic diseases.https://doi.org/10.1002/advs.202306128brain–body interactionmetabolismneuroimmunesympathetic |
| spellingShingle | Wenran Ren Meng Hua Fang Cao Wenwen Zeng The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues Advanced Science brain–body interaction metabolism neuroimmune sympathetic |
| title | The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues |
| title_full | The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues |
| title_fullStr | The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues |
| title_full_unstemmed | The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues |
| title_short | The Sympathetic‐Immune Milieu in Metabolic Health and Diseases: Insights from Pancreas, Liver, Intestine, and Adipose Tissues |
| title_sort | sympathetic immune milieu in metabolic health and diseases insights from pancreas liver intestine and adipose tissues |
| topic | brain–body interaction metabolism neuroimmune sympathetic |
| url | https://doi.org/10.1002/advs.202306128 |
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