Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis

Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis

Abstract Background Microglia pyroptosis-mediated neuroinflammation is thought to be the crucial pathogenesis of sepsis-associated encephalopathy (SAE). Erbin has been reported to be associated with various inflammatory diseases. However, the role of Erbin in SAE and the relationship between Erbin a...

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Bibliographic Details
Main Authors: Guoqing Jing, Jing Zuo, Qing Fang, Min Yuan, Yun Xia, Qiyan Jin, Yuping Liu, Yanlin Wang, Zongze Zhang, Wanhong Liu, Xiaojing Wu, Xuemin Song
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Neuroinflammation
Subjects:
Erbin
NLRP3
Pyroptosis
Sepsis-associated encephalopathy
Microglia
Online Access:https://doi.org/10.1186/s12974-022-02598-5

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