The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome
The components of metabolic syndrome (MetS) and hepatogastrointestinal diseases are widespread worldwide, since many factors associated with lifestyle and diet influence their development and correlation. Due to these growing health problems, it is necessary to search for effective alternatives for...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7229 |
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| author | Alicia Rodríguez-Pastén Nury Pérez-Hernández Javier Añorve-Morga Rubén Jiménez-Alvarado Raquel Cariño-Cortés Teresa Sosa-Lozada Eduardo Fernández-Martínez |
| author_facet | Alicia Rodríguez-Pastén Nury Pérez-Hernández Javier Añorve-Morga Rubén Jiménez-Alvarado Raquel Cariño-Cortés Teresa Sosa-Lozada Eduardo Fernández-Martínez |
| author_sort | Alicia Rodríguez-Pastén |
| collection | DOAJ |
| description | The components of metabolic syndrome (MetS) and hepatogastrointestinal diseases are widespread worldwide, since many factors associated with lifestyle and diet influence their development and correlation. Due to these growing health problems, it is necessary to search for effective alternatives for prevention or adjuvants in treating them. The positive impact of regulated microbiota on health is known; however, states of dysbiosis are closely related to the development of the conditions mentioned above. Therefore, the role of prebiotics, probiotics, or symbiotic complexes has been extensively evaluated; the results are favorable, showing that they play a crucial role in the regulation of the immune system, the metabolism of carbohydrates and lipids, and the biotransformation of bile acids, as well as the modulation of their central receptors FXR and TGR-5, which also have essential immunomodulatory and metabolic activities. It has also been observed that they can benefit the host by displacing pathogenic species, improving the dysbiosis state in MetS. Current studies have reported that paraprobiotics (dead or inactive probiotics) or postbiotics (metabolites generated by active probiotics) also benefit hepatogastrointestinal health. |
| first_indexed | 2024-03-09T21:48:39Z |
| format | Article |
| id | doaj.art-1aeea8504d2f4fdba188199e4363012d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:48:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1aeea8504d2f4fdba188199e4363012d2023-11-23T20:10:14ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313722910.3390/ijms23137229The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic SyndromeAlicia Rodríguez-Pastén0Nury Pérez-Hernández1Javier Añorve-Morga2Rubén Jiménez-Alvarado3Raquel Cariño-Cortés4Teresa Sosa-Lozada5Eduardo Fernández-Martínez6Department of Medicine, Health Sciences School, Autonomous University of Hidalgo State, Pachuca 42090, MexicoPrograma Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Mexico City 07320, MexicoÁrea Académica de Química, Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Mineral de la Reforma 42184, MexicoInstituto de Ciencias Agropecuarias, Universidad Autónoma del Estado de Hidalgo, Av. Universidad km. 1, Tulancingo 43600, MexicoDepartment of Medicine, Health Sciences School, Autonomous University of Hidalgo State, Pachuca 42090, MexicoDepartment of Medicine, Health Sciences School, Autonomous University of Hidalgo State, Pachuca 42090, MexicoLaboratory of Medicinal Chemistry and Pharmacology, Centro de Investigación en Biología de la Reproducción, Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca 42090, MexicoThe components of metabolic syndrome (MetS) and hepatogastrointestinal diseases are widespread worldwide, since many factors associated with lifestyle and diet influence their development and correlation. Due to these growing health problems, it is necessary to search for effective alternatives for prevention or adjuvants in treating them. The positive impact of regulated microbiota on health is known; however, states of dysbiosis are closely related to the development of the conditions mentioned above. Therefore, the role of prebiotics, probiotics, or symbiotic complexes has been extensively evaluated; the results are favorable, showing that they play a crucial role in the regulation of the immune system, the metabolism of carbohydrates and lipids, and the biotransformation of bile acids, as well as the modulation of their central receptors FXR and TGR-5, which also have essential immunomodulatory and metabolic activities. It has also been observed that they can benefit the host by displacing pathogenic species, improving the dysbiosis state in MetS. Current studies have reported that paraprobiotics (dead or inactive probiotics) or postbiotics (metabolites generated by active probiotics) also benefit hepatogastrointestinal health.https://www.mdpi.com/1422-0067/23/13/7229gut microbiotaprebioticsprobioticsmetabolic syndromeliverlipids |
| spellingShingle | Alicia Rodríguez-Pastén Nury Pérez-Hernández Javier Añorve-Morga Rubén Jiménez-Alvarado Raquel Cariño-Cortés Teresa Sosa-Lozada Eduardo Fernández-Martínez The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome International Journal of Molecular Sciences gut microbiota prebiotics probiotics metabolic syndrome liver lipids |
| title | The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome |
| title_full | The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome |
| title_fullStr | The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome |
| title_full_unstemmed | The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome |
| title_short | The Activity of Prebiotics and Probiotics in Hepatogastrointestinal Disorders and Diseases Associated with Metabolic Syndrome |
| title_sort | activity of prebiotics and probiotics in hepatogastrointestinal disorders and diseases associated with metabolic syndrome |
| topic | gut microbiota prebiotics probiotics metabolic syndrome liver lipids |
| url | https://www.mdpi.com/1422-0067/23/13/7229 |
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