Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial
Objective Centipede stings are a common problem in tropical countries. Current treatment guidelines do not include recommendations for antibiotic prophylaxis to prevent the associated bacterial infection since no previous study has assessed the effectiveness of antibiotic treatment in patients bitte...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2021-03-01
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| Series: | Clinical and Experimental Emergency Medicine |
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| Online Access: | http://ceemjournal.org/upload/pdf/ceem-20-110.pdf |
| _version_ | 1828006140165750784 |
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| author | Chanon Changratanakorn Napasawan Fasawang Boriboon Chenthanakit Pakpoom Tansanthong Chanikarn Mapairoje Ratree Tunud Annop Pipopwongpisan Borwon Wittayachamnankul |
| author_facet | Chanon Changratanakorn Napasawan Fasawang Boriboon Chenthanakit Pakpoom Tansanthong Chanikarn Mapairoje Ratree Tunud Annop Pipopwongpisan Borwon Wittayachamnankul |
| author_sort | Chanon Changratanakorn |
| collection | DOAJ |
| description | Objective Centipede stings are a common problem in tropical countries. Current treatment guidelines do not include recommendations for antibiotic prophylaxis to prevent the associated bacterial infection since no previous study has assessed the effectiveness of antibiotic treatment in patients bitten by centipedes. Thus, this study aimed to compare the effectiveness of antibiotic prophylaxis over placebo for the skin infections that occur after a centipede sting. Methods In this randomized, double-blind, multi-center clinical trial conducted in the emergency departments in four hospitals, patients with any history of a centipede sting were prospectively enrolled and divided randomly into two groups. One group received dicloxacillin and the other a placebo. The primary outcome was the incidence of wound infection 3 to 5 days after the centipede sting. Results From December 2014 to October 2015, a total of 83 patients were enrolled in the study and were randomized into antibiotic (n=43) and placebo (n=40) groups. Two patients in the antibiotic group developed wound infections, while none showed wound infection in the placebo group (5% vs. 0%). The wound infection rate did not differ significantly between the two groups (P=0.496). Conclusion Antibiotic prophylaxis may be unnecessary in cases of centipede stings. Proper wound care is an adequate and appropriate treatment for patients with centipede stings. However, the patient should be re-evaluated for detection of secondary bacterial infection. |
| first_indexed | 2024-04-10T07:53:52Z |
| format | Article |
| id | doaj.art-1aef0439106f4f02a415071ea8ae366e |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:53:52Z |
| publishDate | 2021-03-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-1aef0439106f4f02a415071ea8ae366e2023-02-23T07:00:11ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252021-03-0181434710.15441/ceem.20.110317Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trialChanon Changratanakorn0Napasawan Fasawang1Boriboon Chenthanakit2Pakpoom Tansanthong3Chanikarn Mapairoje4Ratree Tunud5Annop Pipopwongpisan6Borwon Wittayachamnankul7 Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand Department of Emergency Medicine, Wiang Nong Long Hospital, Lamphun, Thailand Department of Emergency Medicine, Banthi Hospital, Lamphun, Thailand Department of Emergency Medicine, Li Hospital, Lamphun, Thailand Department of Emergency Medicine, Li Hospital, Lamphun, Thailand Department of Emergency Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandObjective Centipede stings are a common problem in tropical countries. Current treatment guidelines do not include recommendations for antibiotic prophylaxis to prevent the associated bacterial infection since no previous study has assessed the effectiveness of antibiotic treatment in patients bitten by centipedes. Thus, this study aimed to compare the effectiveness of antibiotic prophylaxis over placebo for the skin infections that occur after a centipede sting. Methods In this randomized, double-blind, multi-center clinical trial conducted in the emergency departments in four hospitals, patients with any history of a centipede sting were prospectively enrolled and divided randomly into two groups. One group received dicloxacillin and the other a placebo. The primary outcome was the incidence of wound infection 3 to 5 days after the centipede sting. Results From December 2014 to October 2015, a total of 83 patients were enrolled in the study and were randomized into antibiotic (n=43) and placebo (n=40) groups. Two patients in the antibiotic group developed wound infections, while none showed wound infection in the placebo group (5% vs. 0%). The wound infection rate did not differ significantly between the two groups (P=0.496). Conclusion Antibiotic prophylaxis may be unnecessary in cases of centipede stings. Proper wound care is an adequate and appropriate treatment for patients with centipede stings. However, the patient should be re-evaluated for detection of secondary bacterial infection.http://ceemjournal.org/upload/pdf/ceem-20-110.pdfchilopodainsect bites and stingsantibiotic prophylaxiswound infection |
| spellingShingle | Chanon Changratanakorn Napasawan Fasawang Boriboon Chenthanakit Pakpoom Tansanthong Chanikarn Mapairoje Ratree Tunud Annop Pipopwongpisan Borwon Wittayachamnankul Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial Clinical and Experimental Emergency Medicine chilopoda insect bites and stings antibiotic prophylaxis wound infection |
| title | Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial |
| title_full | Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial |
| title_fullStr | Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial |
| title_full_unstemmed | Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial |
| title_short | Effectiveness of antibiotic prophylaxis in patients with centipede stings: a randomized controlled trial |
| title_sort | effectiveness of antibiotic prophylaxis in patients with centipede stings a randomized controlled trial |
| topic | chilopoda insect bites and stings antibiotic prophylaxis wound infection |
| url | http://ceemjournal.org/upload/pdf/ceem-20-110.pdf |
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